A Retrospective Analysis of Antithrombin III Replacement Therapy for the Treatment of Hepatic Sinusoidal Obstruction Syndrome in Children Following Hematopoietic Stem Cell Transplantation

被引：2
|
作者：
Kim, Miriam [1 ]
Rao, Seema [1 ,3 ]
Eickhoff, Jens C. [2 ]
DeSantes, Kenneth B. [1 ]
Capitini, Christian M. [1 ]
机构：
[1] Univ Wisconsin, Dept Pediat, Carbone Canc Ctr, Sch Med & Publ Hlth, Madison, WI USA
[2] Univ Wisconsin, Dept Biostat & Med Informat, Carbone Canc Ctr, Sch Med & Publ Hlth, Madison, WI USA
[3] Baylor Coll Med, Dept Pediat, Texas Childrens Canc & Hematol Ctr, Houston, TX 77030 USA
来源：
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2020年 / 42卷 / 02期
基金：
美国国家卫生研究院;
关键词：
venoocclusive disease; BMT; stem cell transplantation; sinusoidal obstruction syndrome; antithrombin III; BONE-MARROW-TRANSPLANTATION; VENOOCCLUSIVE DISEASE; PREVENTION; TRIAL; LIVER;
D O I：
10.1097/MPH.0000000000001422
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Hepatic sinusoidal obstruction syndrome (SOS) remains a serious complication of hematopoietic stem cell transplantation (HSCT). In this single institution retrospective case series, 18 children developed SOS after HSCT. Patients were treated with antithrombin III (ATIII), defibrotide, or ATIII followed by defibrotide. Twelve of 13 patients who were treated with ATIII therapy alone had complete resolution of SOS, including 4 of 5 children with severe SOS. In this limited cohort, ATIII was safe and successfully prevented progression of hepatic SOS following HSCT in the majority of children at our center.
引用
收藏
页码：145 / 148
页数：4
相关论文
共 50 条
  • [1] Analysis of risk factors for hepatic sinusoidal obstruction syndrome following allogeneic hematopoietic stem cell transplantation in pediatric patients
    Kloehn, Jaspar
    Brodt, Grit
    Ernst, Jana
    Gruhn, Bernd
    JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2022, 148 (06) : 1447 - 1455
  • [2] Clinical features and risk factors of hepatic sinusoidal obstruction syndrome in children after hematopoietic stem cell transplantation: A single-center experience
    Kartal, Ibrahim
    Albayrak, Canan
    Dagdemir, Ayhan
    Dincer, Oguz Salih
    Simsek, Hulya Kangal
    Ozgen, Unsal
    Albayrak, Davut
    TRANSFUSION AND APHERESIS SCIENCE, 2024, 63 (03)
  • [3] Heparanase polymorphisms: influence on incidence of hepatic sinusoidal obstruction syndrome in children undergoing allogeneic hematopoietic stem cell transplantation
    Seifert, Claudia
    Wittig, Susan
    Arndt, Clemens
    Gruhn, Bernd
    JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2015, 141 (05) : 877 - 885
  • [4] Genetic Susceptibility to Hepatic Sinusoidal Obstruction Syndrome in Pediatric Patients Undergoing Hematopoietic Stem Cell Transplantation
    Ansari, Marc
    Petrykey, Kateryna
    Rezgui, Mohamed Aziz
    Del Vecchio, Veronica
    Cortyl, Jacques
    Ralph, Reginald-Olivier
    Nava, Tiago
    Beaulieu, Patrick
    St-Onge, Pascal
    Mlakar, Simona Jurkovic
    Curtis, Patricia Huezo-Diaz
    Uppugunduri, Chakradhara Rao S.
    Lesne, Laurence
    Theoret, Yves
    Chalandon, Yves
    Bartelink, Imke H.
    Boelens, Jaap-Jan
    Bredius, Robbert G. M.
    Dalle, Jean-Hugues
    Lewis, Victor
    Kangarloo, Bill S.
    Peters, Christina
    Sinnett, Daniel
    Bittencourt, Henrique
    Krajinovic, Maja
    BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2020, 26 (05) : 920 - 927
  • [5] Refined ultrasonographic criteria for sinusoidal obstruction syndrome after hematopoietic stem cell transplantation
    Nishida, Mutsumi
    Sugita, Junichi
    Takahashi, Shuichiro
    Iwai, Takahito
    Sato, Megumi
    Kudo, Yusuke
    Omotehara, Satomi
    Horie, Tatsunori
    Sakano, Ryosuke
    Shibuya, Hitoshi
    Yokota, Isao
    Iguchi, Akihiro
    Teshima, Takanori
    INTERNATIONAL JOURNAL OF HEMATOLOGY, 2021, 114 (01) : 94 - 101
  • [6] Safety and effects of prophylactic defibrotide for sinusoidal obstruction syndrome in hematopoietic stem cell transplantation
    Park, Meerim
    Park, Hyeon Jin
    Eom, Hyeon-Seok
    Kwon, Young Joo
    Park, Jeong A.
    Lim, Yeon Jung
    Yoon, Jong Hyung
    Kong, Sun Young
    Ghim, Thad T.
    Lee, Hye Won
    Yun, Tak
    Park, Byung-Kiu
    ANNALS OF TRANSPLANTATION, 2013, 18 : 36 - 42
  • [7] Analysis of laboratory parameters before the occurrence of hepatic sinusoidal obstruction syndrome in children, adolescents, and young adults after hematopoietic stem cell transplantation
    Johann, Lorena
    Gruhn, Bernd
    JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2024, 150 (01)
  • [8] Hepatic sinusoidal obstruction syndrome after allogeneic hematopoietic stem cell transplantation in adult patients with idiopathic aplastic anemia
    Kim, Hawk
    Lee, Kyoo-Hyung
    Sohn, Sang Kyun
    Jung, Chul Won
    Joo, Young Don
    Kim, Sung Hyun
    Kim, Byung Soo
    Choi, Jung Hye
    Kwak, Jae-Yong
    Kim, Min Kyoung
    Bae, Sung Hwa
    Shin, Ho-Jin
    Won, Jong Ho
    Oh, Sukjoong
    Lee, Won Sik
    Park, Jae-Hoo
    Yoon, Sung-Soo
    LEUKEMIA RESEARCH, 2013, 37 (10) : 1241 - 1247
  • [9] Defibrotide Shows Efficacy in the Prevention of Sinusoidal Obstruction Syndrome After Allogeneic Hematopoietic Stem Cell Transplantation: A Retrospective Study
    Chalandon, Yves
    Mamez, Anne-Claire
    Giannotti, Federica
    Beauverd, Yan
    Dantin, Carole
    Mahne, Elif
    Mappoura, Maria
    Bernard, Fanette
    Ortiz, Carmen de Ramon
    Stephan, Caroline
    Morin, Sarah
    Ansari, Marc
    Simonetta, Federico
    Masouridi-Levrat, Stavroula
    TRANSPLANTATION AND CELLULAR THERAPY, 2022, 28 (11): : 765.e1 - 765.e9
  • [10] Analysis of risk factors for hepatic sinusoidal obstruction syndrome following allogeneic hematopoietic stem cell transplantation in pediatric patients
    Jaspar Kloehn
    Grit Brodt
    Jana Ernst
    Bernd Gruhn
    Journal of Cancer Research and Clinical Oncology, 2022, 148 : 1447 - 1455
12345