Beneficial Effect of Successful Simultaneous Pancreas-Kidney Transplantation on Plasma Profile of Metalloproteinases in Type 1 Diabetes Mellitus Patients

被引：2

作者：

Chudek, Jerzy ^{[1
]}

Kolonko, Aureliusz ^{[2
]}

Ziaja, Jacek ^{[3
]}

Francuz, Tomasz ^{[4
]}

Kaminska, Dorota ^{[5
]}

Owczarek, Aleksander J. ^{[6
]}

Kuczera, Piotr ^{[2
]}

Kujawa-Szewieczek, Agata ^{[2
]}

Kusztal, Mariusz ^{[5
]}

Kowalik, Adrian P. ^{[3
]}

Bozek-Pajak, Dominika ^{[3
]}

Kluz, Joanna ^{[7
]}

Choreza, Piotr ^{[6
]}

Krol, Robert ^{[3
]}

Krajewska, Magdalena ^{[5
]}

Cierpka, Lech ^{[3
]}

Wiecek, Andrzej ^{[2
]}

机构：

[1] Med Univ Silesia, Dept Internal Med & Oncol Chemotherapy, PL-40027 Katowice, Poland

[2] Med Univ Silesia, Dept Nephrol Transplantat & Internal Med, PL-40027 Katowice, Poland

[3] Med Univ Silesia, Dept Gen Vasc & Transplant Surg, PL-40027 Katowice, Poland

[4] Med Univ Silesia, Dept Biochem, PL-40752 Katowice, Poland

[5] Wroclaw Med Univ, Dept Nephrol & Transplantat Med, PL-50556 Wroclaw, Poland

[6] Med Univ Silesia, Dept Pathophysiol, Hlth Promot & Obes Management Unit, PL-40752 Katowice, Poland

[7] Univ Clin Hosp, Dept Angiol Hypertens & Diabetol, PL-50556 Wroclaw, Poland

来源：

JOURNAL OF CLINICAL MEDICINE | 2021年 / 10卷 / 17期

关键词：

arterial stiffness; atherosclerosis; intima-media thickness; matrix metalloproteinases; simultaneous pancreas kidney transplantation; type; 1; diabetes; ARTERIAL STIFFNESS; MATRIX METALLOPROTEINASES; CARDIOVASCULAR OUTCOMES; INSULIN-RESISTANCE; SURVIVAL; CALCIFICATION;

D O I：

10.3390/jcm10173800

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

It is not fully elucidated whether the restoring of normal glucose metabolism after successful simultaneous pancreas-kidney transplantation (SPK) improves vascular wall morphology and function in type 1 diabetic (T1D) patients. Therefore, we compared arterial stiffness, assessed by pulse wave velocity (PWV), carotid intima-media thickness (IMT), and biomarkers of arterial wall calcification in T1D patients after SPK or kidney transplantation alone (KTA). In 39 SPK and 39 KTA adult patients of similar age, PWV, IMT, circulating matrix metalloproteinases (MMPs) and calcification biomarkers were assessed at median 83 months post transplantation. Additionally, carotid plaques were visualized and semi-qualitatively classified. Although PWV and IMT values were similar, the occurrence of atherosclerotic plaques (51.3 vs. 70.3%, p < 0.01) and calcified lesions (35.9 vs. 64.9%, p < 0.05) was lower in SPK patients. There were significantly lower concentrations of MMP-1, MMP-2, MMP-3, and osteocalcin in SPK subjects. Among the analyzed biomarkers, only logMMP-1, logMMP-2, and logMMP-3 concentrations were associated with log HbA(1c). Multivariate stepwise backward regression analysis revealed that MMP-1 and MMP-3 variability were explained only by log HbA(1c). Normal glucose metabolism achieved by SPK is followed by the favorable profile of circulating matrix metalloproteinases, which may reflect the vasoprotective effect of pancreas transplantation.

引用

页数：12

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