Patient values and preferences regarding VTE disease: a systematic review to inform American Society of Hematology guidelines

被引：38

作者：

Etxeandia-Ikobaltzeta, Itziar ^{[1
]}

Zhang, Yuan ^{[1
]}

Brundisini, Francesca ^{[1
]}

Florez, Ivan D. ^{[1
,2
]}

Wiercioch, Wojtek ^{[1
]}

Nieuwlaat, Robby ^{[1
]}

Begum, Housne ^{[1
]}

Cuello, Carlos A. ^{[1
,3
]}

Roldan, Yetiani ^{[1
]}

Chen, Ru ^{[4
]}

Ding, Chengyi ^{[5
]}

Morgan, Rebecca L. ^{[1
]}

Riva, John J. ^{[1
,6
]}

Zhang, Yuqing ^{[1
]}

Charide, Rana ^{[7
]}

Agarwal, Arnav ^{[8
]}

Balduzzi, Sara ^{[9
]}

Morgano, Gian Paolo ^{[1
]}

Jose Yepes-Nunez, Juan ^{[10
]}

Rehman, Yasir ^{[1
]}

Neumann, Ignacio ^{[11
]}

Schwab, Nicole ^{[12
,13
]}

Baldeh, Tejan ^{[1
]}

Braun, Cody ^{[14
]}

Francisca Rodriguez, Maria ^{[15
]}

Schunemann, Holger J. ^{[1
,16
]}

机构：

[1] McMaster Univ, Dept Hlth Res Methods Evidence & Impact, Hamilton, ON, Canada

[2] Univ Antioquia, Dept Pediat, Medellin, Colombia

[3] Tecnol Monterrey, Sch Med, Dept Hlth Qual Improvement, Monterrey, Mexico

[4] Chinese Acad Med Sci & Peking Union Med Coll, Canc Hosp, Natl Canc Ctr, Beijing, Peoples R China

[5] UCL, Dept Epidemiol & Publ Hlth, London, England

[6] McMaster Univ, Dept Family Med, Hamilton, ON, Canada

[7] Amer Univ Beirut, Fac Med, GRADE Ctr, Beirut, Lebanon

[8] Univ Toronto, Dept Med, Toronto, ON, Canada

[9] Univ Modena, Dept Med & Surg Sci Children & Adults, Modena, Italy

[10] Univ Los Andes, Sch Med, Bogota, Colombia

[11] Pontificia Univ Catolica Chile, Dept Internal Med, Santiago, Chile

[12] SickKids Hosp, Toronto, ON, Canada

[13] Univ Toronto, Toronto, ON, Canada

[14] Loyola Univ Med Ctr, Dept Internal Med, Maywood, IL 60153 USA

[15] Univ San Sebastian, Fac Med, Santiago, Chile

[16] McMaster Univ, Hlth Sci Ctr, Dept Med, Hamilton, ON, Canada

来源：

BLOOD ADVANCES | 2020年 / 4卷 / 05期

关键词：

MOLECULAR-WEIGHT HEPARIN; VITAMIN-K ANTAGONISTS; QUALITY-OF-LIFE; CANCER-ASSOCIATED THROMBOSIS; DEEP-VEIN THROMBOSIS; DIRECT ORAL ANTICOAGULANTS; HEALTH STATE VALUATIONS; SHARED DECISION-MAKING; VENOUS THROMBOEMBOLISM; COMPRESSION STOCKINGS;

D O I：

10.1182/bloodadvances.2019000462

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Values and preferences relate to the importance that patients place on health outcomes (eg, bleeding, having a deep venous thrombosis) and are essential when weighing benefits and harms in guideline recommendations. To inform the American Society of Hematology guidelines for management of venous thromboembolism (VTE) disease, we conducted a systematic review of patients' values and preferences related to VTE. We searched Medline, Embase, Cochrane Central Register of Controlled Trials, PsycINFO, and the Cumulative Index to Nursing and Allied Health Literature from inception to April of 2018 (PROSPERO-CRD42018094003). We included quantitative and qualitative studies. We followed Grading of Recommendations Assessment, Development and Evaluation (GRADE) guidance for rating the certainty and presenting findings for quantitative research about the relative importance of health outcomes and a grounded theory approach for qualitative thematic synthesis. We identified 14 quantitative studies (2465 participants) describing the relative importance of VTE-related health states in a widely diverse population of patients, showing overall small to important impact on patients' lives (certainty of the evidence from low to moderate). Additionally, evidence from 34 quantitative studies (6424 participants) and 15 qualitative studies (570 participants) revealed that patients put higher value on VTE risk reduction than on the potential harms of the treatment (certainty of evidence from low to moderate). Studies also suggested a clear preference for oral medication over subcutaneous medication (moderate certainty). The observed variability in health state values may be a result of differences in the approaches used to elicit them and the diversity of included populations rather than true variability in values. This finding highlights the necessity to explore the variability induced by different approaches to ascertain values.

引用

页码：953 / 968

页数：16

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