Noncoding RNAs involved in the STAT3 pathway in glioma

被引：22

作者：

Bian, Zheng ^{[1
]}

Ji, Wei ^{[1
]}

Xu, Bin ^{[1
]}

Huo, Zhengyuan ^{[1
]}

Huang, Hui ^{[1
]}

Huang, Jin ^{[1
]}

Jiao, Jiantong ^{[1
]}

Shao, Junfei ^{[1
]}

Zhang, Xiaolu ^{[1
]}

机构：

[1] Nanjing Med Univ, Wuxi Peoples Hosp, Dept Neurosurg, Wuxi, Jiangsu, Peoples R China

来源：

CANCER CELL INTERNATIONAL | 2021年 / 21卷 / 01期

基金：

中国国家自然科学基金;

关键词：

glioma; miRNA; lncRNAs; circRNAs; STAT3; POSITIVE FEEDBACK LOOP; ACTIVATED STAT3; TEMOZOLOMIDE RESISTANCE; MIRNA BIOGENESIS; TUMOR-SUPPRESSOR; TARGETING STAT3; GENE-EXPRESSION; CELL-MIGRATION; STEM-CELLS; GLIOBLASTOMA;

D O I：

10.1186/s12935-021-02144-y

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Glioma is the most common malignant primary brain tumour in adults. Despite improvements in neurosurgery and radiotherapy, the prognosis of glioma patients remains poor. One of the main limitations is that there are no proper clinical therapeutic targets for glioma. Therefore, it is crucial to find one or more effective targets. Signal transducer and activator of transcription 3 (STAT3) is a member of the STAT family of genes. Abnormal expression of STAT3 is involved in the process of cell proliferation, migration, invasion, immunosuppression, angiogenesis, dryness maintenance, and resistance to radiotherapy and chemotherapy in glioma. Therefore, STAT3 has been considered an ideal therapeutic target in glioma. Noncoding RNAs (ncRNAs) are a group of genes with limited or no protein-coding capacity that can regulate gene expression at the epigenetic, transcriptional and posttranscriptional level. In this review, we summarized the ncRNAs that are correlated with the ectopic expression of STAT3 in glioma.

引用

页数：15

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