Cascade Palladium-Catalyzed Direct Intramolecular Arylation/Alkene Isomerization Sequences: Synthesis of Indoles and Benzofurans

被引：44

作者：

Yagoubi, Myriam ^{[1
]}

Cruz, Ana C. F. ^{[1
]}

Nichols, Paula L. ^{[2
]}

Elliott, Richard L. ^{[2
]}

Willis, Michael C. ^{[1
]}

机构：

[1] Univ Oxford, Dept Chem, Chem Res Lab, Oxford OX1 3TA, England

[2] GlaxoSmithKline, Harlow CM19 5AW, Essex, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 43期

基金：

英国工程与自然科学研究理事会;

关键词：

benzofurans; direct arylation reactions; heterocycles; indoles; palladium; PROTON-ABSTRACTION MECHANISM; CROSS-COUPLING REACTIONS; ONE-POT SYNTHESIS; C-H ACTIVATION; BOND FORMATION; SUBSTITUTED CARBAZOLES; CONSECUTIVE AMINATION; ARYL CHLORIDES; DIBENZOFURANS; HETEROARENES;

D O I：

10.1002/anie.201004097

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

One route, two cycles: A palladium-catalyzed intramolecular direct arylation reaction combined with an isomerization step provided a straightforward synthetic route to both indoles and benzofurans (see scheme). Isolation and functionalization of intermediate alkene isomers allowed the formation of variants having substituents remote from the core. © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：7958 / 7962

页数：5

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