REDfly v3.0: toward a comprehensive database of transcriptional regulatory elements in Drosophila

被引：124

作者：

Gallo, Steven M. ^{[1
,2
]}

Gerrard, Dave T. ^{[3
]}

Miner, David ^{[1
,2
]}

Simich, Michael ^{[4
]}

Des Soye, Benjamin ^{[4
]}

Bergman, Casey M. ^{[3
]}

Halfon, Marc S. ^{[1
,4
,5
,6
]}

机构：

[1] SUNY Buffalo, New York State Ctr Excellence Bioinformat & Life, Buffalo, NY 14203 USA

[2] SUNY Buffalo, Ctr Computat Res, Buffalo, NY 14203 USA

[3] Univ Manchester, Fac Life Sci, Manchester M13 9PT, Lancs, England

[4] SUNY Buffalo, Dept Biol Sci, Buffalo, NY 14214 USA

[5] SUNY Buffalo, Dept Biochem, Buffalo, NY 14214 USA

[6] Roswell Pk Canc Inst, Dept Mol & Cellular Biol, Buffalo, NY 14263 USA

来源：

NUCLEIC ACIDS RESEARCH | 2011年 / 39卷

基金：

美国国家科学基金会;

关键词：

FACTOR-BINDING SITES; GENOME;

D O I：

10.1093/nar/gkq999

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The REDfly database of Drosophila transcriptional cis-regulatory elements provides the broadest and most comprehensive available resource for experimentally validated cis-regulatory modules and transcription factor binding sites among the metazoa. The third major release of the database extends the utility of REDfly as a powerful tool for both computational and experimental studies of transcription regulation. REDfly v3.0 includes the introduction of new data classes to expand the types of regulatory elements annotated in the database along with a roughly 40% increase in the number of records. A completely redesigned interface improves access for casual and power users alike; among other features it now automatically provides graphical views of the genome, displays images of reporter gene expression and implements improved capabilities for database searching and results filtering. REDfly is freely accessible at http://redfly.ccr.buffalo.edu.

引用

页码：D118 / D123

页数：6

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