Genome-Scale Approaches to Investigate Oxidative DNA Damage

被引：7

作者：

Akatsuka, Shinya ^{[1
]}

Toyokuni, Shinya ^{[1
]}

机构：

[1] Nagoya Univ, Grad Sch Med, Dept Pathol & Biol Responses, Showa Ku, Nagoya, Aichi 4668550, Japan

来源：

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION | 2010年 / 47卷 / 02期

关键词：

DNA immunoprecipitation; 8-oxoguanine; acrolein-modified adenine; chromosome territory; oxygenomics; SINGLE NUCLEOTIDE POLYMORPHISM; FORMALDEHYDE CROSS-LINKING; EMBRYONIC STEM-CELLS; CHROMATIN IMMUNOPRECIPITATION; TRANSCRIPTION FACTORS; NUCLEAR-ORGANIZATION; WIDE DISTRIBUTION; GENE-REGULATION; MICROARRAYS; IDENTIFICATION;

D O I：

10.3164/jcbn.10-38R

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

In the trend of biological science after the completion of the human genome project, appreciation of an organism as a system rather than the sum of many molecular functions is necessary. On the investigation of DNA damage and repair, therefore, the orientation toward systematic and comprehensive genome-scale approaches is rapidly growing. The immuno-precipitation-based technique combined with high-density microarrays is one of the promising methods to provide access to such novel research strategies. We propose this sort of research area as oxygenomics.

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收藏

页码：91 / 97

页数：7

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