The development of new isoxazolone based inhibitors of tumor necrosis factor-alpha (TNF-α) production

被引：61

作者：

Laughlin, SK ^{[1
]}

Clark, MP ^{[1
]}

Djung, JF ^{[1
]}

Golebiowski, A ^{[1
]}

Brugel, TA ^{[1
]}

Sabat, M ^{[1
]}

Bookland, RG ^{[1
]}

Laufersweiler, MJ ^{[1
]}

VanRens, JC ^{[1
]}

Townes, JA ^{[1
]}

De, B ^{[1
]}

Hsieh, LC ^{[1
]}

Xu, SC ^{[1
]}

Walter, RL ^{[1
]}

Mekel, MJ ^{[1
]}

Janusz, MJ ^{[1
]}

机构：

[1] Procter & Gamble Pharmaceut, Hlth Care Res Ctr, Mason, OH 45040 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 09期

关键词：

D O I：

10.1016/j.bmcl.2005.02.066

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

4-Aryl-3-pyridyl and 4-aryl-3-pyrimidinyl based tumor necrosis factor-alpha (TNF-alpha) inhibitors, which contain a novel isoxazolone five-membered heterocyclic core are described. Many showed sub-micromolar activity against lipopolysaccharide-induced TNF-alpha production. (c) 2005 Published by Elsevier Ltd.

引用

页码：2399 / 2403

页数：5

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