The PI3K/AKT signaling pathway in cancer: Molecular mechanisms and possible therapeutic interventions

被引：84
作者：
Khezri, Mohammad Rafi [1 ]
Jafari, Reza [2 ]
Yousefi, Keyvan [3 ]
Zolbanin, Naime Majidi [4 ,5 ,6 ]
机构：
[1] Urmia Univ Med Sci, Student Res Comm, Orumiyeh, Iran
[2] Urmia Univ Med Sci, Cellular & Mol Med Inst, Cellular & Mol Res Ctr, Orumiyeh, Iran
[3] Univ Miami, Miller Sch Med, Dept Mol & Cellular Pharmacol, Miami, FL 33146 USA
[4] Urmia Univ Med Sci, Expt & Appl Pharmaceut Sci Res Ctr, Orumiyeh, Iran
[5] Urmia Univ Med Sci, Sch Pharm, Dept Pharmacol & Toxicol, Orumiyeh, Iran
[6] Urmia Univ Med Sci, Sch Fac Pharm, Dept Pharmacol & Toxicol, Sero Rd, Orumiyeh, Iran
来源：
EXPERIMENTAL AND MOLECULAR PATHOLOGY | 2022年 / 127卷
关键词：
Angiogenesis; Apoptosis; Cancer; PI3K; AKT; CELL LUNG-CANCER; INHIBITS TUMOR ANGIOGENESIS; GROWTH-FACTOR RECEPTOR; I KAPPA B; BREAST-CANCER; GASTRIC-CANCER; OVARIAN-CANCER; PANCREATIC-CANCER; UP-REGULATION; COLON-CANCER;
D O I：
10.1016/j.yexmp.2022.104787
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
The human body consists of countless cells with the possibility of excessive and uncontrolled proliferation under certain dysregulated circumstances that could cause abnormal states such as cancer. Phosphatidylinositol 3 kinase (PI3K) and its downstream target, Protein kinase B or AKT, play a critical role in cell survival, proliferation, differentiation, migration, and metabolism. Research studies have examined the aberrant expression of signaling molecules that regulate PI3K/AKT pathway with the purpose of target discovery. The present review aims to recapitulate the relationship between the PI3K/AKT signaling pathway and factors contributing to initiation and development of various cancers. In addition, therapeutic interventions regulating this signaling pathway have been summarized.
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页数：12
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