Emerging role of myeloperoxidase and oxidant stress markers in cardiovascular risk assessment

被引：127
作者：
Brennan, ML
Hazen, SL
机构：
[1] Cleveland Clin Fdn, Ctr Cardiovasc Diagnost & Prevent, Cleveland, OH 44195 USA
[2] Cleveland Clin Fdn, Dept Cell Biol, Cleveland, OH 44195 USA
[3] Cleveland Clin Fdn, Dept Cardiovasc Med, Cleveland, OH 44195 USA
来源：
CURRENT OPINION IN LIPIDOLOGY | 2003年 / 14卷 / 04期
关键词：
myeloperoxidase; cardiovascular disease; inflammation; oxidation; nitric oxide;
D O I：
10.1097/00041433-200308000-00003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The inflammatory protein myeloperoxidase is present, active and mechanistically poised to participate in the initiation and progression of cardiovascular disease. The many links between myeloperoxidase, oxidation and cardiovascular disease suggest this leukocyte protein may have clinical utility in risk stratification for cardiovascular disease status and outcomes.
引用
收藏
页码：353 / 359
页数：7
相关论文
共 54 条
  • [1] Nitric oxide is a physiological substrate for mammalian peroxidases
    Abu-Soud, HM
    Hazen, SL
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (48) : 37524 - 37532
  • [2] Peroxidases inhibit nitric oxide (NO) dependent bronchodilation: Development of a model describing NO-peroxidase interactions
    Abu-Soud, HM
    Khassawneh, MY
    Sohn, JT
    Murray, P
    Haxhiu, MA
    Hazen, SL
    [J]. BIOCHEMISTRY, 2001, 40 (39) : 11866 - 11875
  • [3] Reactive brominating species produced by myeloperoxidase target the vinyl ether bond of plasmalogens -: Disparate utilization of sodium halides in the production of α-halo fatty aldehydes
    Albert, CJ
    Crowley, JR
    Hsu, FF
    Thukkani, AK
    Ford, DA
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (07) : 4694 - 4703
  • [4] Myeloperoxidase and plasminogen activator inhibitor 1 play a central role in ventricular remodeling after myocardial infarction
    Askari, AT
    Brennan, ML
    Zhou, XR
    Drinko, J
    Morehead, A
    Thomas, JD
    Topol, EJ
    Hazen, SL
    Penn, MS
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 197 (05) : 615 - 624
  • [5] Baldus S, 2001, J CLIN INVEST, V108, P1759
  • [6] Spatial mapping of pulmonary and vascular nitrotyrosine reveals the pivotal role of myeloperoxidase as a catalyst for tyrosine nitration in inflammatory diseases
    Baldus, S
    Eiserich, JP
    Brennan, ML
    Jackson, RM
    Alexander, CB
    Freeman, BA
    [J]. FREE RADICAL BIOLOGY AND MEDICINE, 2002, 33 (07) : 1010 - 1019
  • [7] Blake Gavin J, 2000, Curr Control Trials Cardiovasc Med, V1, P161, DOI 10.1186/CVM-1-3-161
  • [8] A tale of two controversies -: Defining both the role of peroxidases in nitrotyrosine formation in vivo using eosinophil peroxidase and myeloperoxidase-deficient mice, and the nature of peroxidase-generated reactive nitrogen species
    Brennan, ML
    Wu, WJ
    Fu, XM
    Shen, ZZ
    Song, W
    Frost, H
    Vadseth, C
    Narine, L
    Lenkiewicz, E
    Borchers, MT
    Lusis, AJ
    Lee, JJ
    Lee, NA
    Abu-Soud, HM
    Ischiropoulos, H
    Hazen, SL
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (20) : 17415 - 17427
  • [9] Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease
    Brown, BG
    Zhao, XQ
    Chait, A
    Fisher, LD
    Cheung, MC
    Morse, JS
    Dowdy, AA
    Marino, EK
    Bolson, EL
    Alaupovic, P
    Frohlich, J
    Albers, JJ
    Serafini, L
    Huss-Frechette, E
    Wang, S
    DeAngelis, D
    Dodek, A
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2001, 345 (22) : 1583 - 1592
  • [10] Widespread coronary inflammation in unstable angina
    Buffon, A
    Biasucci, LM
    Liuzzo, G
    D'Onofrio, G
    Crea, F
    Maseri, A
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2002, 347 (01) : 5 - 12
123456