Candida tropicalis in human disease

被引：107

作者：

Chai, Louis Yi Ann ^{[1
,3
]}

Denning, David W. ^{[2
]}

Warn, Peter ^{[2
]}

机构：

[1] Natl Univ Singapore Hosp, Dept Med, Singapore 119074, Singapore

[2] Univ Manchester, Manchester Acad Hlth Sci Ctr, NIHR Translat Res Facil Resp Med, Univ Hosp S Manchester NHS Fdn Trust, Manchester, Lancs, England

[3] Radboud Univ Nijmegen, Dept Med, Med Ctr, NL-6500 HB Nijmegen, Netherlands

来源：

CRITICAL REVIEWS IN MICROBIOLOGY | 2010年 / 36卷 / 04期

基金：

英国医学研究理事会;

关键词：

BLOOD-STREAM INFECTIONS; BROTH MICRODILUTION METHOD; IN-VITRO ACTIVITY; INTENSIVE-CARE-UNIT; SUSCEPTIBILITY TESTING SUBCOMMITTEE; AMPLIFIED POLYMORPHIC DNA; VOICE PROSTHESIS BIOFILMS; NEUTROPENIC MURINE MODEL; NON-ALBICANS CANDIDA; ANTIFUNGAL SUSCEPTIBILITY;

D O I：

10.3109/1040841X.2010.489506

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Candida tropicalis is one of the more common Candida causing human disease in tropical countries; the frequency of invasive disease varies by geography causing 3-66% of candidaemia. C. tropicalis is taxonomically close to C. albicans and shares many pathogenic traits. C. tropicalis is particularly virulent in neutropenic hosts commonly with hematogenous seeding to peripheral organs. For candidaemia and invasive candidiasis amphotericin B or an echinocandin are recommended as first-line treatment, with extended-spectrum triazoles acceptable alternatives. Primary fluconazole resistance is uncommon but may be induced on exposure. Physicians in regions where C. tropicalis is common need to be mindful of this lesser-described pathogen.</.

引用

页码：282 / 298

页数：17

共 196 条

[11] Experimental induction of fluconazole resistance in Candida tropicalis ATCC 750 [J].