Immunoglobulin G4-related Liver Disease Overlapping with Non-alcoholic Steatohepatitis That Was Diagnosed Simultaneously with Autoimmune Pancreatitis: A Case Report and Review of the Literature

被引：3

作者：

Matsumoto, Kotaro ^{[1
]}

Kikuchi, Kentaro ^{[2
]}

Kuniyoshi, Noriyuki ^{[1
]}

Tsunashima, Hiromichi ^{[1
]}

Sekine, Katsunori ^{[1
]}

Mabuchi, Masatoshi ^{[1
]}

Doi, Shinpei ^{[1
]}

Zen, Yoh ^{[3
]}

Miyakawa, Hiroshi ^{[2
]}

机构：

[1] Teikyo Univ, Dept Gastroenterol, Mizonokuchi Hosp, Kawasaki, Kanagawa, Japan

[2] Teikyo Univ, Dept Internal Med 4, Mizonokuchi Hosp, Kawasaki, Kanagawa, Japan

[3] Kobe Univ, Dept Diagnost Pathol, Grad Sch Med, Kobe, Hyogo, Japan

来源：

INTERNAL MEDICINE | 2019年 / 58卷 / 24期

关键词：

autoimmune hepatitis; autoimmune pancreatitis; IgG4-related disease; non-alcoholic steatohepatitis; overlap; HEPATIC INFLAMMATORY PSEUDOTUMOR; CELLS; AUTOANTIBODIES; PREVALENCE; STEATOSIS;

D O I：

10.2169/internalmedicine.3204-19

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 70-year-old woman was referred to our hospital due to symptoms of dry eyes, dry mouth, and epigastric pain. Computed tomography showed distal pancreatic swelling, liver edge dullness and surface irregularities. Serum anti-nuclear antibody titers, immunoglobulin G and IgG4 levels were elevated. Autoimmune pancreatitis (AIP) was diagnosed based on endoscopic findings and a histopathological examination. Her AIP improved after starting prednisolone treatment. A liver biopsy revealed interface hepatitis with lymphoplasmacyte and IgG4-positive plasma cell infiltration. In addition, non-alcoholic steatohepatitis (NASH) was diagnosed based on the presence of parenchymal steatosis, ballooning hepatocytes, and pericellular fibrosis. We experienced a unique liver disease case showing IgG4-related liver disease overlapping with NASH.

引用

收藏

页码：3537 / 3543

页数：7

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