Astaxanthin is a natural pigment that is used as a dietary supplement. Many experiments have shown that astaxanthin has positive effects against various diseases including diabetes. Adonixanthin and adonirubin are biosynthetic intermediates of beta-carotene to astaxanthin and possess the same radical scavenging activity as astaxanthin. In this study, we evaluated the antidiabetic effect on pancreatic beta cells of astaxanthin-rich extract (ARE) derived from Paracoccus carotinifaciens, which contains several carotenoids such as astaxanthin, adonir-ubin, and adonixanthin. Specifically, we studied the effects on insulin secretion and cytoprotection as well as on intracellular reactive oxygen species (ROS) generation and mitochondrial superoxide production. As a result, pretreatment with ARE derived from P. carotinifaciens increased insulin secretion under the condition of 20 mM glucose stimulation in iGL cells. In addition, ARE derived from P. carotinifaciens significantly decreased strep-tozotocin (STZ)-induced cell death in INS-1 cells, and isobologram analysis revealed the synergistic effects among astaxanthin, adonixanthin, and adonirubin. We clarified that the production control of mitochondrial superoxide was involved in the mechanism of these effects. These findings suggest that ARE derived from P. carotinifaciens may be used to treat diabetes by increasing glucose-stimulated insulin secretion and protecting pancreatic beta cells.
机构:
Univ Catania, Dept Drug Sci, Sect Biochem, Viale Doria 6, I-95125 Catania, ItalyUniv Catania, Dept Drug Sci, Sect Biochem, Viale Doria 6, I-95125 Catania, Italy
Malfa, Giuseppe Antonio
Tomasello, Barbara
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Univ Catania, Dept Drug Sci, Sect Biochem, Viale Doria 6, I-95125 Catania, ItalyUniv Catania, Dept Drug Sci, Sect Biochem, Viale Doria 6, I-95125 Catania, Italy
Tomasello, Barbara
Acquaviva, Rosaria
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Univ Catania, Dept Drug Sci, Sect Biochem, Viale Doria 6, I-95125 Catania, ItalyUniv Catania, Dept Drug Sci, Sect Biochem, Viale Doria 6, I-95125 Catania, Italy
Acquaviva, Rosaria
La Mantia, Alfonsina
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机构:
Univ Catania, Dept Drug Sci, Sect Biochem, Viale Doria 6, I-95125 Catania, ItalyUniv Catania, Dept Drug Sci, Sect Biochem, Viale Doria 6, I-95125 Catania, Italy
La Mantia, Alfonsina
Pappalardo, Francesco
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机构:
Univ Catania, Dept Drug Sci, Sect Biochem, Viale Doria 6, I-95125 Catania, ItalyUniv Catania, Dept Drug Sci, Sect Biochem, Viale Doria 6, I-95125 Catania, Italy
Pappalardo, Francesco
Ragusa, Monica
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机构:
Magna Graecia Univ Catanzaro, Dept Expt & Clin Med, I-88100 Catanzaro, ItalyUniv Catania, Dept Drug Sci, Sect Biochem, Viale Doria 6, I-95125 Catania, Italy
Ragusa, Monica
Renis, Marcella
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机构:
Univ Catania, Dept Drug Sci, Sect Biochem, Viale Doria 6, I-95125 Catania, ItalyUniv Catania, Dept Drug Sci, Sect Biochem, Viale Doria 6, I-95125 Catania, Italy
Renis, Marcella
Di Giacomo, Claudia
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Univ Catania, Dept Drug Sci, Sect Biochem, Viale Doria 6, I-95125 Catania, ItalyUniv Catania, Dept Drug Sci, Sect Biochem, Viale Doria 6, I-95125 Catania, Italy
机构:
Kagoshima Univ, United Grad Sch Agr Sci, Korimoto 1-21-24, Kagoshima 8900065, Japan
Univ Ryukyus, PAK Res Ctr, Nishihara, Okinawa 9030213, JapanKagoshima Univ, United Grad Sch Agr Sci, Korimoto 1-21-24, Kagoshima 8900065, Japan
Shahinozzaman, Md
Taira, Nozomi
论文数: 0引用数: 0
h-index: 0
机构:
Univ Ryukyus, Dept Biosci & Biotechnol, Fac Agr, Senbaru 1, Nishihara, Okinawa 9030213, JapanKagoshima Univ, United Grad Sch Agr Sci, Korimoto 1-21-24, Kagoshima 8900065, Japan
Taira, Nozomi
Ishii, Takahiro
论文数: 0引用数: 0
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机构:
Kagoshima Univ, United Grad Sch Agr Sci, Korimoto 1-21-24, Kagoshima 8900065, Japan
Univ Ryukyus, Dept Biosci & Biotechnol, Fac Agr, Senbaru 1, Nishihara, Okinawa 9030213, JapanKagoshima Univ, United Grad Sch Agr Sci, Korimoto 1-21-24, Kagoshima 8900065, Japan
Ishii, Takahiro
Halim, Mohammad A.
论文数: 0引用数: 0
h-index: 0
机构:
Red Green Res Ctr, Div Comp Aided Drug Design, 218 Elephant Rd, Dhaka 1205, BangladeshKagoshima Univ, United Grad Sch Agr Sci, Korimoto 1-21-24, Kagoshima 8900065, Japan
Halim, Mohammad A.
Hossain, Md Amzad
论文数: 0引用数: 0
h-index: 0
机构:
Kagoshima Univ, United Grad Sch Agr Sci, Korimoto 1-21-24, Kagoshima 8900065, Japan
Univ Ryukyus, Subtrop Field Sci Ctr, Senbaru 1, Nishihara, Okinawa 9030213, JapanKagoshima Univ, United Grad Sch Agr Sci, Korimoto 1-21-24, Kagoshima 8900065, Japan
Hossain, Md Amzad
Tawata, Shinkichi
论文数: 0引用数: 0
h-index: 0
机构:
Univ Ryukyus, PAK Res Ctr, Nishihara, Okinawa 9030213, Japan
Univ Ryukyus, Dept Biosci & Biotechnol, Fac Agr, Senbaru 1, Nishihara, Okinawa 9030213, JapanKagoshima Univ, United Grad Sch Agr Sci, Korimoto 1-21-24, Kagoshima 8900065, Japan
机构:
Astellas Pharma Inc, Drug Discovery Res, Tsukuba, Ibaraki 3058585, JapanAstellas Pharma Inc, Drug Discovery Res, Tsukuba, Ibaraki 3058585, Japan
Oshima, Hiroyuki
Yoshida, Shigeru
论文数: 0引用数: 0
h-index: 0
机构:
Astellas Pharma Inc, Drug Discovery Res, Tsukuba, Ibaraki 3058585, JapanAstellas Pharma Inc, Drug Discovery Res, Tsukuba, Ibaraki 3058585, Japan
Yoshida, Shigeru
Ohishi, Takahide
论文数: 0引用数: 0
h-index: 0
机构:
Astellas Pharma Inc, Drug Discovery Res, Tsukuba, Ibaraki 3058585, JapanAstellas Pharma Inc, Drug Discovery Res, Tsukuba, Ibaraki 3058585, Japan
Ohishi, Takahide
Matsui, Tetsuo
论文数: 0引用数: 0
h-index: 0
机构:
Astellas Pharma Inc, Drug Discovery Res, Tsukuba, Ibaraki 3058585, JapanAstellas Pharma Inc, Drug Discovery Res, Tsukuba, Ibaraki 3058585, Japan
Matsui, Tetsuo
Tanaka, Hirotsugu
论文数: 0引用数: 0
h-index: 0
机构:
Astellas Pharma Inc, Drug Discovery Res, Tsukuba, Ibaraki 3058585, JapanAstellas Pharma Inc, Drug Discovery Res, Tsukuba, Ibaraki 3058585, Japan
Tanaka, Hirotsugu
Yonetoku, Yasuhiro
论文数: 0引用数: 0
h-index: 0
机构:
Astellas Pharma Inc, Drug Discovery Res, Tsukuba, Ibaraki 3058585, JapanAstellas Pharma Inc, Drug Discovery Res, Tsukuba, Ibaraki 3058585, Japan
Yonetoku, Yasuhiro
Shibasaki, Masayuki
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h-index: 0
机构:
Astellas Pharma Inc, Drug Discovery Res, Tsukuba, Ibaraki 3058585, JapanAstellas Pharma Inc, Drug Discovery Res, Tsukuba, Ibaraki 3058585, Japan
Shibasaki, Masayuki
Uchiyama, Yasuo
论文数: 0引用数: 0
h-index: 0
机构:
Juntendo Univ, Grad Sch Med, Dept Cell Biol & Neurosci, Bunkyo Ku, Tokyo 1138421, JapanAstellas Pharma Inc, Drug Discovery Res, Tsukuba, Ibaraki 3058585, Japan
机构:
Sichuan Univ, W China Sch Pharm, Dept Pharmacol, Chengdu 610041, Sichuan, Peoples R ChinaSichuan Univ, W China Sch Pharm, Dept Pharmacol, Chengdu 610041, Sichuan, Peoples R China
Chen, Zhong-Hua
Li, Jie
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机构:
Sichuan Univ, W China Sch Pharm, Dept Pharmacognosy, Chengdu 610041, Sichuan, Peoples R ChinaSichuan Univ, W China Sch Pharm, Dept Pharmacol, Chengdu 610041, Sichuan, Peoples R China
Li, Jie
Liu, Jie
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h-index: 0
机构:
Sichuan Univ, W China Sch Pharm, Minist Educ, Key Lab Drug Targeting, Chengdu 610041, Sichuan, Peoples R ChinaSichuan Univ, W China Sch Pharm, Dept Pharmacol, Chengdu 610041, Sichuan, Peoples R China
Liu, Jie
Zhao, Yuan
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h-index: 0
机构:
Sichuan Univ, W China Sch Pharm, Dept Pharmacol, Chengdu 610041, Sichuan, Peoples R ChinaSichuan Univ, W China Sch Pharm, Dept Pharmacol, Chengdu 610041, Sichuan, Peoples R China
Zhao, Yuan
Zhang, Pu
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Sichuan Univ, W China Sch Pharm, Dept Pharmacol, Chengdu 610041, Sichuan, Peoples R ChinaSichuan Univ, W China Sch Pharm, Dept Pharmacol, Chengdu 610041, Sichuan, Peoples R China
Zhang, Pu
Zhang, Meng-Xue
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Sichuan Univ, W China Sch Pharm, Dept Pharmacol, Chengdu 610041, Sichuan, Peoples R ChinaSichuan Univ, W China Sch Pharm, Dept Pharmacol, Chengdu 610041, Sichuan, Peoples R China
Zhang, Meng-Xue
Zhang, Liu
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机构:
Sichuan Univ, W China Sch Pharm, Dept Pharmacol, Chengdu 610041, Sichuan, Peoples R ChinaSichuan Univ, W China Sch Pharm, Dept Pharmacol, Chengdu 610041, Sichuan, Peoples R China
Zhang, Liu
AMERICAN JOURNAL OF CHINESE MEDICINE,
2008,
36
(05):
: 939
-
951
机构:
Kyung Hee Univ, Coll Oriental Med, Seoul 130701, South KoreaKyung Hee Univ, Coll Oriental Med, Seoul 130701, South Korea
Joo, Hye-Eun
Lee, Hyo-Jung
论文数: 0引用数: 0
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机构:
Kyung Hee Univ, Coll Oriental Med, Seoul 130701, South Korea
Korea Res Inst Biosci & Biotechnol, Med Genom Res Ctr, Taejon 306809, South KoreaKyung Hee Univ, Coll Oriental Med, Seoul 130701, South Korea
Lee, Hyo-Jung
Sohn, Eun Jung
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Kyung Hee Univ, Coll Oriental Med, Seoul 130701, South KoreaKyung Hee Univ, Coll Oriental Med, Seoul 130701, South Korea
Sohn, Eun Jung
Lee, Min-Ho
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h-index: 0
机构:
Kyung Hee Univ, Coll Life Sci & Biotechnol, Seoul 130701, South KoreaKyung Hee Univ, Coll Oriental Med, Seoul 130701, South Korea
Lee, Min-Ho
Ko, Hyun-Suk
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h-index: 0
机构:
Kyung Hee Univ, Coll Oriental Med, Seoul 130701, South KoreaKyung Hee Univ, Coll Oriental Med, Seoul 130701, South Korea
Ko, Hyun-Suk
Jeong, Soo-Jin
论文数: 0引用数: 0
h-index: 0
机构:
Kyung Hee Univ, Coll Oriental Med, Seoul 130701, South KoreaKyung Hee Univ, Coll Oriental Med, Seoul 130701, South Korea
Jeong, Soo-Jin
Lee, Hyo-Jeong
论文数: 0引用数: 0
h-index: 0
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Kyung Hee Univ, Coll Oriental Med, Seoul 130701, South KoreaKyung Hee Univ, Coll Oriental Med, Seoul 130701, South Korea
Lee, Hyo-Jeong
Kim, Sung-Hoon
论文数: 0引用数: 0
h-index: 0
机构:
Kyung Hee Univ, Coll Oriental Med, Seoul 130701, South KoreaKyung Hee Univ, Coll Oriental Med, Seoul 130701, South Korea
机构:
Univ Sains Malaysia USM, Inst Res Mol Med INFORMM, Gelugor 11800, Penang, MalaysiaUniv Sains Malaysia USM, Inst Res Mol Med INFORMM, Gelugor 11800, Penang, Malaysia
Yuan, Khaw Shin
Sathiabalan, Neshalini
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sains Malaysia USM, Inst Res Mol Med INFORMM, Gelugor 11800, Penang, MalaysiaUniv Sains Malaysia USM, Inst Res Mol Med INFORMM, Gelugor 11800, Penang, Malaysia
Sathiabalan, Neshalini
Wei, Ong Khang
论文数: 0引用数: 0
h-index: 0
机构:
Quest Int Univ, Fac Med, Dept Pharmacol, Ipoh 30250, Perak, MalaysiaUniv Sains Malaysia USM, Inst Res Mol Med INFORMM, Gelugor 11800, Penang, Malaysia
Wei, Ong Khang
Lan, Chew Ai
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sains Malaysia USM, Inst Res Mol Med INFORMM, Gelugor 11800, Penang, MalaysiaUniv Sains Malaysia USM, Inst Res Mol Med INFORMM, Gelugor 11800, Penang, Malaysia
机构:
Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R ChinaSun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China
Li, Xue-Wen
Huang, Meixiang
论文数: 0引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R ChinaSun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China
Huang, Meixiang
Lo, Kakei
论文数: 0引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R ChinaSun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China
Lo, Kakei
Chen, Wei-Li
论文数: 0引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R ChinaSun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China
Chen, Wei-Li
He, Ying-Yan
论文数: 0引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R ChinaSun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China
He, Ying-Yan
Xu, Yongli
论文数: 0引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R ChinaSun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China
Xu, Yongli
Zheng, Huizhen
论文数: 0引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R ChinaSun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China
Zheng, Huizhen
Hu, Haiyan
论文数: 0引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R ChinaSun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China
Hu, Haiyan
Wang, Jun
论文数: 0引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R ChinaSun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China
机构:
Hallym Univ, Inst New Frontier Res Team, Res Inst Med Bio Convergence, Chunchon, South KoreaHallym Univ, Inst New Frontier Res Team, Res Inst Med Bio Convergence, Chunchon, South Korea
Park, Chan Hum
Noh, Jeong Sook
论文数: 0引用数: 0
h-index: 0
机构:
Tongmyong Univ, Dept Food Sci & Nutr, Busan, South KoreaHallym Univ, Inst New Frontier Res Team, Res Inst Med Bio Convergence, Chunchon, South Korea
Noh, Jeong Sook
Jeon, Jin Pyeong
论文数: 0引用数: 0
h-index: 0
机构:
Hallym Univ, Coll Med, Dept Neurosurg, Chunchon, South Korea
Hallym Univ, Coll Med, Dept Neurosurg, Chunchon 24252, South KoreaHallym Univ, Inst New Frontier Res Team, Res Inst Med Bio Convergence, Chunchon, South Korea
Jeon, Jin Pyeong
Yokozawa, Takako
论文数: 0引用数: 0
h-index: 0
机构:
Univ Toyama, Grad Sch Sci & Engn Res, Toyama, Japan
Univ Toyama, Grad Sch Sci & Engn Res, 3190 Gofuku, Toyama 9308555, JapanHallym Univ, Inst New Frontier Res Team, Res Inst Med Bio Convergence, Chunchon, South Korea