High serum oestradiol concentrations in IVF cycles increase the risk of pregnancy complications related to abnormal placentation

被引:135
作者
Farhi, Jacob [1 ]
Ben Haroush, Avi
Andrawus, Nejmi
Pinkas, Haim
Sapir, Onit
Fisch, Benjamin
Ashkenazi, Jacob
机构
[1] Helen Schneider Hosp Women, Dept Obstet & Gynecol, Infertil & IVF Unit, Rabin Med Ctr, IL-49100 Petah Tiqwa, Israel
关键词
implantation; IVF; oestradiol concentrations; placentation; pregnancy complications; CONTROLLED OVARIAN HYPERSTIMULATION; ENDOMETRIAL RECEPTIVITY; UTERINE RECEPTIVITY; IMPLANTATION; STIMULATION;
D O I
10.1016/j.rbmo.2010.04.022
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
The study was designed to evaluate the isolated effect of high serum oestradiol concentration on human chorionic gonadotrophin (HCG) day in IVF cycles on endometrial receptivity and placentation. A retrospective cohort included all women attending the IVF unit in 2006 and 2007, with the best prognosis to achieve pregnancy: age (<38 years), less than three IVF cycles, transfer of two highest grade embryos and no evidence of factors known to impair implantation or that are associated with increased risk of pregnancy complications. The total included 280 patients were categorized into three groups according to their serum oestradiol concentration on HCG day: group 1, oestradiol <5000 pmol/l, group 2, oestradiol in the range 5000-10,000 pmol/l and group 3, oestradiol in the range of 10,000-15,000 pmol/l. No significant differences were found between the groups in implantation, pregnancy and abortion rates. The high oestradiol group was characterized by high rate (20.8%) of pregnancy complications related to abnormal placentation - fetal growth restriction, pregnancy-induced hypertension and abnormal implantation of the placenta. Hence, the decision to perform embryo transfer in high-responder patients should take into consideration both possible risks of ovarian hyperstimulation syndrome and pregnancy complications related to abnormal placentation. (C) 2010, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:331 / 337
页数:7
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