A structural insight into lead neurotoxicity and calmodulin activation by heavy metals

被引：48
作者：
Kursula, Petri [1 ]
Majava, Viivi [1 ]
机构：
[1] Univ Oulu, Dept Biochem, Oulu, Finland
来源：
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS | 2007年 / 63卷
关键词：
D O I：
10.1107/S1744309107034525
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Calmodulin is a calcium sensor that is also capable of binding and being activated by other metal ions. Of specific interest in this respect is lead, which is known to be neurotoxic and to have a very high affinity towards calmodulin. Crystal structures of human calmodulin complexed with lead and barium ions have been solved. The results will help in understanding the activation mechanisms of calmodulin by different heavy metals and will provide a detailed view of a putative target for lead neurotoxicity in humans.
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页码：653 / 656
页数：4
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