EXPRESSION OF MATRIX METALLOPROTEINASE-1,-7,-9,-13, Ki-67, AND HER-2 IN EPITHELIAL-MYOEPITHELIAL SALIVARY GLAND CANCER

被引：17
|
作者：
Luukkaa, Heikki [1 ]
Klemi, Pekka [2 ]
Leivo, Ilmo [3 ]
Makitie, Antti A. [1 ,4 ]
Irish, Jonathan [5 ,6 ]
Gilbert, Ralph [5 ,6 ]
Perez-Ordonez, Bayardo [7 ]
Hirsimaki, Pirkko [2 ]
Vahlberg, Tero [8 ]
Kivisaari, Atte [9 ,10 ]
Kahari, Veli-Matti [9 ,10 ]
Grenman, Reidar [1 ,11 ]
机构：
[1] Univ Turku, Turku Univ Hosp, Dept Otorhinolaryngol Head & Neck Surg, Turku, Finland
[2] Univ Turku, Dept Pathol, Turku, Finland
[3] Univ Helsinki, Cent Hosp, Dept Pathol, Haartman Inst, Helsinki, Finland
[4] Univ Helsinki, Cent Hosp, Dept Otorhinolaryngol Head & Neck Surg, Helsinki, Finland
[5] Univ Toronto, Univ Hlth Network, Princess Margaret Hosp, Dept Otolaryngol Head & Neck Surg, Toronto, ON, Canada
[6] Univ Toronto, Univ Hlth Network, Princess Margaret Hosp, Dept Surg Oncol, Toronto, ON, Canada
[7] Univ Toronto, Univ Hlth Network, Dept Pathol, Toronto, ON, Canada
[8] Univ Turku, Dept Biostat, Turku, Finland
[9] Univ Turku, Dept Dermatol, Turku, Finland
[10] Univ Turku, Med Res Lab, Turku, Finland
[11] Univ Turku, Dept Med Biochem & Mol Biol, Turku, Finland
来源：
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2010年 / 32卷 / 08期
基金：
芬兰科学院;
关键词：
MMP; matrix metalloproteinase; Ki-67; HER-2; salivary gland cancer; epithelial-myoepithelial carcinoma; IN-SITU HYBRIDIZATION; ADENOID CYSTIC CARCINOMA; SQUAMOUS-CELL CARCINOMAS; EX PLEOMORPHIC ADENOMA; PARAFFIN SECTIONS; MUCOEPIDERMOID CARCINOMAS; PROGNOSTIC-SIGNIFICANCE; TISSUE INHIBITORS; DUCT CARCINOMAS; MIB-1; ANTIBODY;
D O I：
10.1002/hed.21277
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Background. The expression of matrix metalloproteinases (MMPs) in epithelial-myoepithelial salivary gland carcinoma has not been studied previously. Methods. Immunohistochemistry for MMP-1. -7. -9, -13, Ki-67, and HER-2, as well as HER-2 gene amplification by silver enhanced in situ hybridization was performed in a series of 12 paraffin-embedded histopathologic samples of patients from Canada and Finland. Results. A positive MMP-13 (p = .0022), higher MMP-13 (p = .0274), and higher MMP-9 (p = .0274) index (multiplication of staining intensity by percentage of the positive cells) predicted better overall survival. In disease-specific analysis, higher MMP-9 index (p = .0327) predicted better survival. A higher volume corrected index (VCI) of Ki-67 (p = .0339) predicted worse disease-specific survival. In 1 patient, HER-2 oncogene amplification was observed. Conclusion. MMPs and Ki-67 may have prognostic impact in epithelial-myoepithelial carcinoma. (C) 2009 Wiley Periodicals, Inc. Head Neck 32: 1019-1027, 2010
引用
收藏
页码：1019 / 1027
页数：9
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