Serum hepcidin level leand its clinical significance in maintenance hemodialysis patients

被引：4
作者：
Zhang, P. [1 ]
Yang, L. -N. [1 ]
Wang, G. [1 ]
Li, F. -E. [1 ]
Tang, F. [1 ]
机构：
[1] Peoples Liberat Army, Hosp Chinese 452, Dept Nephrol, Chengdu, Peoples R China
来源：
GENETICS AND MOLECULAR RESEARCH | 2014年 / 13卷 / 04期
关键词：
Hepcidin; Chronic renal failure; Maintenance hemodialysis; PEPTIDE HEPCIDIN; IRON; ANEMIA; FERROPORTIN; DIALYSIS; GENE;
D O I：
10.4238/2014.November.27.16
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Hepcidin is a key protein of iron metabolism, which may play an important role in the prognosis of patients with chronic renal failure on maintenance hemodialysis. The purpose of this study was to investigate the relationship between the prognosis of maintenance hemodialysis patients and serum hepcidin level. We enrolled 60 patients on maintenance hemodialysis and 30 healthy controls from March 2012 to December 2012 in our hospital. Peripheral blood samples were collected to determine hepcidin by an ELISA method. Hepcidin levels of hemodialysis patients were significantly higher than those of the healthy control group. Hepcidin level was positively correlated with the degree of anemia in the dialysis group. Therefore, we conclude that hepcidin level is significantly increased in patients with chronic renal failure on maintenance hemodialysis and that increased hepcidin seriously affects the prognosis of chronic renal failure.
引用
收藏
页码：9883 / 9888
页数：6
相关论文
共 16 条
  • [1] De Domenico I, 2007, MOL BIOL CELL, V18, P2569, DOI 10.1091/mbc.E07-01-0060
  • [2] Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats
    Frazer, DM
    Wilkins, SJ
    Becker, EM
    Vulpe, CD
    McKie, AT
    Trinder, D
    Anderson, GJ
    [J]. GASTROENTEROLOGY, 2002, 123 (03) : 835 - 844
  • [3] Ganz T., 2006, Hematology Am Soc Hematol Educ Program, V29-35, P507, DOI DOI 10.1182/ASHEDUCATION-2006.1.29
  • [4] Influence of dialysis with polyamide vs haemophan haemodialysers on monokines and complement activation during a 4-month long-term study
    Girndt, M
    Heisel, O
    Köhler, H
    [J]. NEPHROLOGY DIALYSIS TRANSPLANTATION, 1999, 14 (03) : 676 - 682
  • [5] Iron-overload induces oxidative DNA damage in the human colon carcinoma cell line HT29 clone 19A
    Glei, M
    Latunde-Dada, GO
    Klinder, A
    Becker, TW
    Hermann, U
    Voigt, K
    Pool-Zobel, BL
    [J]. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 2002, 519 (1-2) : 151 - 161
  • [6] Horwitz LD, 1999, VASC MED, V4, P93, DOI 10.1177/1358836X9900400207
  • [7] LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity
    Krause, A
    Neitz, S
    Mägert, HJ
    Schulz, A
    Forssmann, WG
    Schulz-Knappe, P
    Adermann, K
    [J]. FEBS LETTERS, 2000, 480 (2-3) : 147 - 150
  • [8] Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
    Nemeth, E
    Tuttle, MS
    Powelson, J
    Vaughn, MB
    Donovan, A
    Ward, DM
    Ganz, T
    Kaplan, J
    [J]. SCIENCE, 2004, 306 (5704) : 2090 - 2093
  • [9] Severe iron deficiency anemia in transgenic mice expressing liver hepcidin
    Nicolas, G
    Bennoun, M
    Porteu, A
    Mativet, S
    Beaumont, C
    Grandchamp, B
    Sirito, M
    Sawadogo, M
    Kahn, A
    Vaulont, S
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (07) : 4596 - 4601
  • [10] The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation
    Nicolas, G
    Chauvet, C
    Viatte, L
    Danan, JL
    Bigard, X
    Devaux, I
    Beaumont, C
    Kahn, A
    Vaulont, S
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2002, 110 (07) : 1037 - 1044
12