In Vivo Prediction of Tuberculosis-Associated Cavity Formation in Rabbits

被引：11

作者：

Luna, Brian ^{[1
]}

Kubler, Andre ^{[1
,6
]}

Larsson, Christer ^{[1
]}

Foster, Brent ^{[4
]}

Bagci, Ulas ^{[4
]}

Mollura, Daniel J. ^{[4
]}

Jain, Sanjay K. ^{[1
,2
,3
]}

Bishai, William R. ^{[1
,2
,5
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Johns Hopkins Ctr TB Res, Baltimore, MD USA

[2] Johns Hopkins Univ, Sch Med, Ctr Infect & Inflammat Imaging Res, Baltimore, MD USA

[3] Johns Hopkins Univ, Sch Med, Dept Pediat, Baltimore, MD 21205 USA

[4] NIH, Ctr Infect Dis Imaging, Dept Radiol & Imaging Sci, Bethesda, MD 20892 USA

[5] Howard Hughes Med Inst, Chevy Chase, MD USA

[6] Univ London Imperial Coll Sci Technol & Med, Dept Med, London SW7 2AZ, England

来源：

JOURNAL OF INFECTIOUS DISEASES | 2015年 / 211卷 / 03期

基金：

美国国家卫生研究院; 瑞典研究理事会;

关键词：

CT; F-18]-FDG; PET; tuberculosis; MYCOBACTERIUM-TUBERCULOSIS;

D O I：

10.1093/infdis/jiu449

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The presence of cavitary lesions in patients with tuberculosis poses a significant clinical concern due to the risk of infectivity and the risk of antibiotic treatment failure. We describe 2 algorithms that use noninvasive positron emission tomography (PET) and computed tomography (CT) to predict the development of cavitary lesions in rabbits. Analysis of the PET region of interest predicted cavitary disease with 100% sensitivity and 76% specificity, and analysis of the CT region of interest predicted cavitary disease with 83.3% sensitivity and 76.9% specificity. Our results show that restricting our analysis to regions with high [F-18]-fluorodeoxyglucose uptake provided the best combination of sensitivity and specificity.

引用

页码：481 / 485

页数：5

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