A randomized clinical trial of a new orthodontic appliance to improve upper airway obstruction in infants with Pierre Robin sequence

被引:87
作者
Buchenau, Wolfgang
Urschitz, Michael S.
Sautermeister, Judit
Bacher, Margit
Herberts, Tina
Arand, Joerg
Poets, Christian F.
机构
[1] Univ Hosp Tubingen, Dept Neonatol, D-72076 Tubingen, Germany
[2] Univ Hosp Tubingen, Dept Orthodont, D-72076 Tubingen, Germany
[3] Univ Hosp Tubingen, Dept Med Biometry, D-72076 Tubingen, Germany
关键词
D O I
10.1016/j.jpeds.2007.02.063
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Objective To test the hypothesis that a new orthodontic appliance with a velar extension that shifts the tongue anteriorly would reduce upper airway obstruction in infants with Pierre Robin sequence (PRS). Studydesign Eleven infants with PRS (median age, 3 days) and an apnea index (Al) >3 were studied. The effect of the new appliance on the Al was compared with that of a conventional appliance without a velar extension by using a crossover study design with random allocation. Results Compared with baseline (mean boolean AND l, 13.8), there was a significant decrease in the AI with the new appliance (3.9; P value <.001), but no change with the conventional appliance (14.8; P =.842), Thus, the relative change in At was -71% (95% Cl, -84--49) for the new appliance and,+8% (95% C1, -52-142) for the conventional appliance, which was significantly different (P =.004). No severe adverse effects were observed. Conclusion This new orthodontic appliance appears to be safe and effective in reducing upper airway obstruction in infants with PRS.
引用
收藏
页码:145 / 149
页数:5
相关论文
共 33 条
[1]   Management of upper airway obstruction in Pierre Robin sequence [J].
Bath, AP ;
Bull, PD .
JOURNAL OF LARYNGOLOGY AND OTOLOGY, 1997, 111 (12) :1155-1157
[2]   INCIDENCE OF THE ANOMALAD,ROBIN (PIERRE-ROBIN SYNDROME) [J].
BUSH, PG ;
WILLIAMS, AJ .
BRITISH JOURNAL OF PLASTIC SURGERY, 1983, 36 (04) :434-437
[3]   THE PIERRE-ROBIN-SEQUENCE - REVIEW OF 125 CASES AND EVOLUTION OF TREATMENT MODALITIES [J].
CAOUETTELABERGE, L ;
BAYET, B ;
LAROCQUE, Y .
PLASTIC AND RECONSTRUCTIVE SURGERY, 1994, 93 (05) :934-942
[4]  
DENNISON WM, 1965, PEDIATRICS, V36, P336
[5]  
Denny A, 2002, PLAST RECONSTR SURG, V109, P896, DOI 10.1097/00006534-200203000-00011
[6]   Mandibular distraction osteogenesis in very young patients to correct airway obstruction [J].
Denny, AD ;
Talisman, R ;
Hanson, PR ;
Recinos, RF .
PLASTIC AND RECONSTRUCTIVE SURGERY, 2001, 108 (02) :302-311
[7]  
Elliott Margaret A., 1995, Pediatric Dentistry, V17, P106
[8]   BEDSIDE POLYSOMNOGRAPHY AS AN ADJUNCT IN THE MANAGEMENT OF INFANTS WITH ROBIN-SEQUENCE [J].
GILHOOLY, JT ;
SMITH, JD ;
HOWELL, LL ;
DESCHAINE, BL ;
RICHEY, SL .
PLASTIC AND RECONSTRUCTIVE SURGERY, 1993, 92 (01) :23-27
[9]  
Hotz M, 1982, Swed Dent J Suppl, V15, P89
[10]  
Loughlin GM, 1996, AM J RESP CRIT CARE, V153, P866