Mechanisms of peroxynitrite-induced [Ca2+]i increase in single neuronal cell

被引:2
作者
Yi, Y
Cai, D
Gao, ZH
Yang, XL
Qu, AL
Xu, HB [1 ]
Wang, XM
Han, SP
机构
[1] Huazhong Univ Sci & Technol, Inst Biophys & Biochem, Wuhan 430074, Peoples R China
[2] Beijing Med Univ, Neurosci Res Ctr, Beijing 100083, Peoples R China
[3] St Louis Univ, Sch Med, Dept Pharmacol & Physiol Sci, St Louis, MO 63104 USA
来源
CHINESE SCIENCE BULLETIN | 1998年 / 43卷 / 20期
基金
中国国家自然科学基金;
关键词
peroxynitrite (ONOO-); intracellular calcium concentration ([Ca2+](i)); MN9D cells;
D O I
10.1007/BF02883974
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The mechanism of peroxynitrite (ONOO-)-induced [Ca2+ ](i) increase in single MN9D cell (Dopaminergic neuroblastoma cell line) was studied by using Fura-2 microfluorometric technique. The results show that ONOO- caused a rapid increase of [Ca2+](i) when ONOO- was puffed to the cell. Removing Ca2+ from the bath or using calcium channel antagonist (CdCl2, Nifedipine) greatly inhibited the [Ca2+](i) increase induced by ONOO-, suggesting that the opening of L-Ca2+ channel makes a great contribution to the [Ca2+](i) increase. The effect of sulfhydryl reductive agent (DTT) on ONOO- -induced [Ca2+](i) increase suggests that ONOO- -activating L-Ca2+ channel is partly related to its oxidative speciality.
引用
收藏
页码:1727 / 1732
页数:6
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