Prediction of fluid responsiveness based on liver compression-induced blood pressure changes in children after cardiac surgery

BACKGROUND: This study evaluated whether liver compression-induced blood pressure changes can predict fluid responsiveness in children after cardiac surgery. METHODS: Children aged <5 years who were undergoing cardiac surgery were evaluated after the sternum was closed. Before fluid loading, the right upper abdomen was compressed at a pressure of 30 mmHg for 15 seconds and changes in blood pressure waves were recorded. Then, 10 mL/kg of colloid solution was administered. Systolic arterial pressure (SAP), diastolic arterial pressure (DAP), central venous pressure (CVP), systolic pressure variation (SPV), stroke volume, and respiratory variation in aortic blood flow peak velocity (Delta Vpeak) were measured before and after fluid loading. A volume responder was defined as >15% increase in Stroke Volume Index. RESULTS: There were 17 responders and 13 non-responders. During liver compression, mean percent increase in DAP (Delta DAP) was significantly higher in the responder group (10.5%) than in the non-responder group (5.4%) (P=0.008). A.DAP of 5% during liver compression and a Delta Vpeak of >12% were able to predict fluid responsiveness (P=0.01 and 0.02, respectively). However, changes in SAP during liver compression, SPV, and CVP had no predictive value. The area under the receiver operating characteristic curve of Delta DAP and Delta Vpeak were 0.778 and 0.765, respectively. CONCLUSIONS:Delta DAP induced by liver compression and Delta Vpeak can be used to predict fluid responsiveness in mechanically ventilated children. Liver compression can be a simple and practical method to assess volume status in children.