T cell exclusion, immune privilege, and the tumor microenvironment

被引：1783

作者：

Joyce, Johanna A. ^{[1
]}

Fearon, Douglas T. ^{[2
,3
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Canc Biol & Genet Program, New York, NY 10065 USA

[2] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA

[3] Weill Cornell Med Sch, Joan & Sanford I Weill Dept Med, Dept Microbiol & Immunol, New York, NY 10065 USA

来源：

SCIENCE | 2015年 / 348卷 / 6230期

关键词：

LYMPHOCYTE INFILTRATION; VASCULAR NORMALIZATION; ANTI-PD-L1; ANTIBODY; PROGNOSTIC-FACTOR; TNF-ALPHA; CANCER; IMMUNOTHERAPY; SUPPRESSION; ACTIVATION; EXPRESSION;

D O I：

10.1126/science.aaa6204

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Effective immunotherapy promotes the killing of cancer cells by cytotoxic T cells. This requires not only that cancer-specific Tcells be generated, but also that these Tcells physically contact cancer cells. The coexistence in some patients of cancer cells and T cells that recognize them indicates that tumors may exhibit the phenomenon of immune privilege, in which immunogenic tissue is protected from immune attack. Here, we review the evidence that stromal cells of the tumor microenvironment mediate this restriction by excluding T cells from the vicinity of cancer cells. Overcoming this T cell checkpoint may thus enable optimal immunotherapy.

引用

页码：74 / 80

页数：7

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