A case of longitudinally extensive transverse myelitis following vaccination against Covid-19

被引：66

作者：

Pagenkopf, Claudia ^{[1
]}

Suedmeyer, Martin ^{[1
,2
]}

机构：

[1] Klinikum Ernst von Bergmann, Dept Neurol, Charlottenstr 72, D-14467 Potsdam, Germany

[2] Univ Dusseldorf, Med Fac, Dept Neurol, Dusseldorf, Germany

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2021年 / 358卷

关键词：

Longitudinally extensive transverse myelitis; Transverse myelitis; Covid-19; vaccination; SARS-CoV-2; Vaccine related disorder;

D O I：

10.1016/j.jneuroim.2021.577606

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background: Longitudinally extensive transverse myelitis (LETM) is a rare subtype of transverse myelitis (TM) that potentially results in relevant disability. Apart from association to neuromyelitis optica and other chronic demyelinating diseases of the central nervous system, many other aetiologies are known. Particularly systemic infections and vaccination are considered potential triggers for immune mediated inflammation of the spinal cord. In the course of the current Covid-19 pandemic several cases of TM following Covid-19 infection have been described. Here we present a case of LETM following vaccination against Covid-19 with AZD1222, AstraZeneca. An extensive diagnostic work up was performed to rule out alternative causes, including prior and current Covid19 infection. Conclusion: To our knowledge this is first case of LETM possibly related to Covid-19 vaccination that is published after marketing authorisation of various vaccine candidates.

引用

页数：5

共 27 条

[1] Transverse myelitis and vaccines: a multi-analysis [J].

Agmon-Levin, N. ;

Kivity, S. ;

Szyper-Kravitz, M. ;

Shoenfeld, Y. .

LUPUS, 2009, 18 (13) :1198-1204

[2]

Akkad W, 2010, ARCH NEUROL-CHICAGO, V67, P1018, DOI 10.1001/archneurol.2010.167

[3] Myelopathy associated with SARS-COV-2 infection. A systematic review [J].

Artemiadis, Artemios ;

Liampas, Andreas ;

Hadjigeorgiou, Loizos ;

Zis, Panagiotis .

NEUROLOGICAL RESEARCH, 2021, 43 (08) :633-641

[4] Proposed diagnostic criteria and nosology of acute transverse myelitis [J].

Barnes, G ;

Benjamin, S ;

Bowen, JD ;

Cutter, N ;

de Lateur, BJ ;

Dietrich, WD ;

Dowling, MM ;

Griffin, JW ;

Hummers, L ;

Irani, D ;

Jorens, PG ;

Kaplin, AI ;

Katz, JD ;

Kerr, DA ;

Krishnan, C ;

Levy, CE ;

Lucchinetti, C ;

Lynn, DJ ;

Mandler, RN ;

McArthur, JC ;

McDonald, JW ;

Morrison, L ;

Pardo-Villamizar, C ;

Pidcock, FS ;

Ransohoff, R ;

Roos, KL ;

Trovato, MK ;

Vollmer, TL ;

Wegener, ST ;

Weinshenker, BG ;

Wingerchuk, DM .

NEUROLOGY, 2002, 59 (04) :499-505

[5] Acute transverse myelitis in COVID-19 infection [J].

Chow, Chian Chiang Nicholas ;

Magnussen, John ;

Ip, Jerome ;

Su, Yuen .

BMJ CASE REPORTS, 2020, 13 (08)

[6] Neurological associations of COVID-19 [J].

Ellul, Mark A. ;

Benjamin, Laura ;

Singh, Bhagteshwar ;

Lant, Suzannah ;

Michael, Benedict Daniel ;

Easton, Ava ;

Kneen, Rachel ;

Defres, Sylviane ;

Sejvar, Jim ;

Solomon, Tom .

LANCET NEUROLOGY, 2020, 19 (09) :767-783

[7] Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial [J].

Folegatti, Pedro M. ;

Ewer, Katie J. ;

Aley, Parvinder K. ;

Angus, Brian ;

Becker, Stephan ;

Belij-Rammerstorfer, Sandra ;

Bellamy, Duncan ;

Bibi, Sagida ;

Bittaye, Mustapha ;

Clutterbuck, Elizabeth A. ;

Dold, Christina ;

Faust, Saul N. ;

Finn, Adam ;

Flaxman, Amy L. ;

Hallis, Bassam ;

Heath, Paul ;

Jenkin, Daniel ;

Lazarus, Rajeka ;

Makinson, Rebecca ;

Minassian, Angela M. ;

Pollock, Katrina M. ;

Ramasamy, Maheshi ;

Robinson, Hannah ;

Snape, Matthew ;

Tarrant, Richard ;

Voysey, Merryn ;

Green, Catherine ;

Douglas, Alexander D. ;

Hill, Adrian V. S. ;

Lambe, Teresa ;

Gilbert, Sarah C. ;

Pollard, Andrew J. .

LANCET, 2020, 396 (10249) :467-478

[8] Spinal cord involvement in COVID-19: A review [J].

Garg, Ravindra Kumar ;

Paliwal, Vimal Kumar ;

Gupta, Ankit .

JOURNAL OF SPINAL CORD MEDICINE, 2023, 46 (03) :390-404

[9] ANA Investigates: Neurological Complications of COVID-19 Vaccines [J].

Goss, Adeline L. ;

Samudralwar, Rohini D. ;

Das, Rohit R. ;

Nath, Avindra .

ANNALS OF NEUROLOGY, 2021, 89 (05) :856-857

[10] Cerebrospinal fluid findings in aquaporin-4 antibody positive neuromyelitis optica: Results from 211 lumbar punctures [J].

Jarius, S. ;

Paul, F. ;

Franciotta, D. ;

Ruprecht, K. ;

Ringelstein, M. ;

Bergamaschi, R. ;

Rommer, P. ;

Kleiter, I. ;

Stich, O. ;

Reuss, R. ;

Rauer, S. ;

Zettl, U. K. ;

Wandinger, K. P. ;

Melms, A. ;

Aktas, O. ;

Kristoferitsch, W. ;

Wildemann, B. .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 2011, 306 (1-2) :82-90

← 1 2 3 →