Mig-6 is essential for glucose homeostasis and thermogenesis in brown adipose tissue

被引：1

作者：

Choung, Sorim ^{[1
]}

Kim, Ji Min ^{[2
,3
]}

Joung, Kyong Hye ^{[2
,3
]}

Kim, Hyun Jin ^{[3
]}

Kang, Seon Mee ^{[4
]}

Jeong, Jae-Wook ^{[5
]}

Ku, Bon Jeong ^{[1
,3
]}

机构：

[1] Chungnam Natl Univ, Coll Med, Res Inst Med Sci, Daejeon 35015, South Korea

[2] Chungnam Natl Univ, Sejong Hosp, Dept Endocrinol, Sejong 30099, South Korea

[3] Chungnam Natl Univ, Coll Med, Dept Internal Med, 282 Munhwa Ro, Daejeon 35015, South Korea

[4] Busan Paik Hosp, Inje Univ, Dept Internal Med, Coll Med, Busan 47392, South Korea

[5] Michigan State Univ, Dept Obstet Gynecol & Reprod Biol, Grand Rapids, MI 49503 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2021年 / 572卷

基金：

新加坡国家研究基金会;

关键词：

Mig-6; Brown adipose tissue; Thermogenesis; Glucose; NEGATIVE REGULATOR; ENERGY-EXPENDITURE; EXPRESSION; OBESITY; UCP1; GENE; FAT;

D O I：

10.1016/j.bbrc.2021.07.088

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Brown adipose tissue (BAT) is an anti-obese and anti-diabetic tissue that stimulates energy expenditure in the form of adaptive thermogenesis through uncoupling protein 1 (UCP1). Mitogen-inducible gene-6 (Mig-6) is a negative regulator of epidermal growth factor receptor (EGFR) that interacts with many cellular partners and has multiple cellular functions. We have recently reported that Mig-6 is associated with diabetes and metabolic syndrome. However, its function in BAT is unknown. We generated a brown adipocyte-specific Mig-6 knock-in mouse (BKI) to examine the role of Mig-6 in BAT. Mig-6 BKI mice had improved glucose tolerance on a normal chow diet. Mig-6 BKI mice also revealed activated thermo-genesis and the size of the BAT lipid droplets was reduced. Additionally, Mig-6 regulated cAMP-PKA signaling-induced UCP1 expression in brown adipocytes. Taken together, these results demonstrate that Mig-6 affects glucose tolerance and thermogenesis in BAT. (c) 2021 Elsevier Inc. All rights reserved.

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页码：92 / 97

页数：6

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