Recently Uncontrolled Glycemia in Diabetic Patients Is Associated with the Severity of Intracranial Atherosclerosis

Background and Purpose: Diabetes mellitus is a specific risk factor for intracranial atherosclerosis (ICAS) regardless of race. However, it is largely unknown whether poor glycemic control is associated with the severity of ICAS in diabetic patients. Methods: We selected diabetic patients with acute ischemic stroke who were prospectively registered between March 2005 and December 2015. The patients who had a high-risk source of cardiogenic embolism were excluded. ICAS was graded from 0 to 3 by the number of significant (>= 50%) stenoses on intracranial magnetic resonance angiography, and was divided into 4 types: unilateral anterior, bilateral anterior, posterior, and anterior plus posterior. Ordinal and multinomial regression tests were applied for the factors influencing the number and types of ICAS. Results: A total of 774 patients with noncardioembolic acute ischemic stroke with diabetes were enrolled. The multiplicity of ICAS was independently associated with age (odds ratio [OR], 1.035 per 1 year, 1.018-1.052; P <.001), hypertension (OR, 1.992, 1.336-2.965; P =.001), and glycated hemoglobin (HbA1c; OR, 1.207 per 1%, 1.089-1.338; P <.001) in the ordinal regression model. In multinomial regression, bilateral anterior stenosis tended to be correlated with age (OR, 1.042, 1.0081.077; P =.016) and HbA1c (OR, 1.201 per 1%,.991-1.520; P =.057). Both anterior and posterior stenoses were significantly associated with age (OR, 1.056, 1.029-1.084; P <.001), hypertension (OR, 2.584, 1.404-4.762; P =.002), and HbA1c (OR, 1.272, 1.070-1.511; P =.006). Conclusions: Age, concomitant hypertension, and HbA1c were factors associated with multiple intracranial stenoses. Further study is warranted to elucidate whether poor glycemic control facilitates ICAS in diabetic patients. (C) 2017 National Stroke Association. Published by Elsevier Inc. All rights reserved.