Prognostic Significance of Lymphocyte Infiltrate Localization in Triple-Negative Breast Cancer

被引:5
作者
Ceprnja, Toni [1 ]
Mrklic, Ivana [1 ]
Peric Balja, Melita [2 ]
Marusic, Zlatko [3 ]
Blazicevic, Valerija [4 ]
Spagnoli, Giulio Cesare [5 ]
Juretic, Antonio [6 ]
Capkun, Vesna [7 ]
Tecic Vuger, Ana [8 ]
Vrdoljak, Eduard [9 ]
Tomic, Snjezana [1 ]
机构
[1] Univ Split, Univ Hosp Ctr Split, Sch Med, Dept Pathol Forens Med & Cytol, Split 21000, Croatia
[2] Univ Hosp Ctr Sestre Milosrdnice, Dept Pathol, Zagreb 10000, Croatia
[3] Zagreb Univ, Hosp Ctr, Dept Pathol, Zagreb 10000, Croatia
[4] Univ Hosp Osijek, Dept Pathol, Osijek 31000, Croatia
[5] CNR, Inst Translat Pharmacol, I-00133 Rome, Italy
[6] Univ Zagreb, Clin Hosp Sveti Duh, Sch Med, Dept Oncol, Zagreb 10000, Croatia
[7] Univ Split, Univ Hosp Ctr Split, Sch Med, Dept Nucl Med, Split 21000, Croatia
[8] Univ Hosp Ctr Sestre Milosrdnice, Dept Oncol, Zagreb 10000, Croatia
[9] Univ Split, Univ Hosp Ctr Split, Dept Oncol, Split 21000, Croatia
来源
JOURNAL OF PERSONALIZED MEDICINE | 2022年 / 12卷 / 06期
关键词
triple-negative breast cancer; cancer testis antigens; immunotherapy; NY-ESO-1; PD-L1; tumor-infiltrating lymphocytes; lymphoid aggregates; TUMOR-ASSOCIATED ANTIGENS; TESTIS ANTIGEN; EXPRESSION; NY-ESO-1; CELLS; ASSOCIATION; METASTASES; DOCETAXEL; CARCINOMA; ESTROGEN;
D O I
10.3390/jpm12060941
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
High infiltration by tumor-infiltrating lymphocytes (TILs) is associated with favorable prognosis in different tumor types, but the clinical significance of their spatial localization within the tumor microenvironment is debated. To address this issue, we evaluated the accumulation of intratumoral TILs (itTILs) and stromal TILs (sTILs) in samples from 97 patients with early triple-negative breast cancer (TNBC) in the center (sTIL central) and periphery (sTIL peripheral) of tumor tissues. Moreover, the presence of primary and secondary lymphoid aggregates (LAs) and the expression levels of the cancer testis antigen (CTA), NY-ESO-1, and PD-L1 were explored. High infiltration by itTILs was observed in 12/97 samples (12.3%), unrelated to age, Ki67 expression, tumor size, histologic type and grade, and LA presence. NY-ESO-1 was expressed in tumor cells in 37 samples (38%), with a trend suggesting a correlation with itTIL infiltration (p = 0.0531). PD-L1 expression was detected in immune cells in 47 samples (49%) and was correlated with histologic grade, sTILs, and LA formation. The presence of primary LAs was significantly correlated with better disease-free survival (DFS) (p = 0.027). Moreover, no tumor progression was observed during >40 months of clinical follow up in the 12 patients with high itTILs or in the 14 patients with secondary LAs. Thus, careful evaluation of lymphoid infiltrate intratumoral localization might provide important prognostic information.
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页数:14
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