MR imaging tracking of inflammation-activatable engineered neutrophils for targeted therapy of surgically treated glioma

被引：177

作者：

Wu, Meiying ^{[1
]}

Zhang, Haixian ^{[1
,2
]}

Tie, Changjun ^{[1
,3
]}

Yan, Chunhong ^{[1
]}

Deng, Zhiting ^{[1
]}

Wan, Qian ^{[1
]}

Liu, Xin ^{[1
]}

Yan, Fei ^{[1
]}

Zheng, Hairong ^{[1
]}

机构：

[1] Chinese Acad Sci, Paul C Lauterbur Res Ctr Biomed Imaging, Inst Biomed & Hlth Engn, Shenzhen Inst Adv Technol, Shenzhen 518055, Peoples R China

[2] Fudan Univ, Shanghai Canc Ctr, Dept Ultrasound, Shanghai 200032, Peoples R China

[3] Guangzhou Univ Chinese Med, Shenzhen Hosp, Shenzhen 518034, Peoples R China

来源：

NATURE COMMUNICATIONS | 2018年 / 9卷

基金：

中国博士后科学基金;

关键词：

MESENCHYMAL STEM-CELLS; BLOOD-BRAIN-BARRIER; IRON-OXIDE NANOPARTICLES; DRUG-DELIVERY; MAGNETIC-RESONANCE; MALIGNANT GLIOMAS; CONTRAST AGENTS; TUMOR; PH; GLIOBLASTOMA;

D O I：

10.1038/s41467-018-07250-6

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cell-based drug delivery systems have shown promising capability for tumor-targeted therapy owing to the intrinsic tumor-homing and drug-carrying property of some living cells. However, imaging tracking of their migration and bio-effects is urgently needed for clinical application, especially for glioma. Here, we report the inflammation-activatable engineered neutrophils by internalizing doxorubicin-loaded magnetic mesoporous silica nanoparticles (ND-MMSNs) which can provide the potential for magnetic resonance (MR) imaging tracking of the drug-loaded cells to actively target inflamed brain tumor after surgical resection of primary tumor. The phagocytized D-MMSNs possess high drug loading efficiency and do not affect the host neutrophils' viability, thus remarkably improving intratumoral drug concentration and delaying relapse of surgically treated glioma. Our study offers a new strategy in targeted cancer theranostics through combining the merits of living cells and nanoparticle carriers.

引用

页数：13

共 57 条

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