Organoids from the Human Fetal and Adult Pancreas

被引：43

作者：

Balak, Jeetindra R. A. ^{[1
]}

Juksar, Juri ^{[2
]}

Carlotti, Francoise ^{[1
]}

Lo Nigro, Antonio ^{[2
]}

de Koning, Eelco J. P. ^{[1
,2
]}

机构：

[1] Leiden Univ, Med Ctr, Dept Internal Med, Nephrol, Albinusdreef 2, NL-2333 ZA Leiden, Netherlands

[2] Hubrecht Inst Dev Biol & Stem Cell Res, Utrecht, Netherlands

来源：

CURRENT DIABETES REPORTS | 2019年 / 19卷 / 12期

关键词：

Organoids; 3D culture; Pancreas; Stemcells; Regeneration; Development; Diabetes Mellitus; Type; 1; BETA-CELL MASS; COLONY-FORMING CELLS; IN-VITRO EXPANSION; STEM-CELLS; PROGENITOR CELLS; SELF-RENEWAL; DISTINCT POPULATIONS; MOUSE PANCREAS; CANCER; ENDOCRINE;

D O I：

10.1007/s11892-019-1261-z

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose of Review Novel 3D organoid culture techniques have enabled long-term expansion of pancreatic tissue. This review comprehensively summarizes and evaluates the applications of primary tissue-derived pancreatic organoids in regenerative studies, disease modelling, and personalized medicine. Recent Findings Organoids derived from human fetal and adult pancreatic tissue have been used to study pancreas development and repair. Generated adult human pancreatic organoids harbor the capacity for clonal expansion and endocrine cell formation. In addition, organoids have been generated from human pancreatic ductal adenocarcinoma in order to study tumor behavior and assess drug responses. Summary Pancreatic organoids constitute an important translational bridge between in vitro and in vivo models, enhancing our understanding of pancreatic cell biology. Current applications for pancreatic organoid technology include studies on tissue regeneration, disease modelling, and drug screening.

引用

页数：10

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