miRNAs in normal and malignant B cells

被引：12

作者：

Kotani, Ai ^{[1
,2
]}

Harnprasopwat, Ratanakanit ^{[1
]}

Toyoshima, Takae ^{[1
]}

Kawamata, Toyotaka ^{[1
]}

Tojo, Arinobu ^{[1
,2
]}

机构：

[1] Univ Tokyo, Div Mol Therapy, Adv Clin Res Ctr, Inst Med Sci,Minato Ku, Tokyo 1088639, Japan

[2] Univ Tokyo, Dept Hematol & Oncol, Inst Med Sci, Tokyo 1088639, Japan

来源：

INTERNATIONAL JOURNAL OF HEMATOLOGY | 2010年 / 92卷 / 02期

关键词：

miRNA; ALL; CLL; Malignant lymphoma; EBV; ACUTE LYMPHOBLASTIC-LEUKEMIA; DOWN-REGULATION; EXPRESSION; RNA; ACTIVATION; MICRORNAS; IDENTIFICATION; APOPTOSIS; LYMPHOMA; SURVIVAL;

D O I：

10.1007/s12185-010-0633-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

MicroRNAs (miRNA) are small noncoding RNAs that posttranscriptionally regulate expression of target mRNAs. In animals, miRNAs control many developmental and physiological processes. It has recently revealed that miRNAs critically work in B cell development and some B cell malignancy and that their expression profiles well correlate with its prognosis and phenotype. This review overviews these interesting findings and discuss a possibility that miRNA is a promising target for therapeutic and diagnostic tool for B cell malignancy.

引用

页码：255 / 261

页数：7

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