Chemoenzymatic synthesis of the C-13 side chain of paclitaxel (Taxol) and docetaxel (Taxotere)

被引：50
作者：
Hamamoto, H
Mamedov, VA
Kitamoto, M
Hayashi, N
Tsuboi, S [1 ]
机构：
[1] Okayama Univ, Fac Engn, Dept Appl Chem, Okayama 7008530, Japan
[2] Okayama Univ, Fac Environm Sci & Technol, Dept Environm Chem & Mat, Okayama 7008530, Japan
来源：
TETRAHEDRON-ASYMMETRY | 2000年 / 11卷 / 22期
关键词：
D O I：
10.1016/S0957-4166(00)00418-3
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Reduction of methyl 3-chloro-2-oxo-3-phenylpropanoate with various reducing agents gave syn- and anti-3-chloro-2-hydroxy-3-phenylpropanoates 3, which underwent an efficient lipase-catalyzed resolution. All four diastereomers were subsequently converted to N-benzoyl-(2R,3S)-3-phenylisoserine methyl ester, C-13 side chain analogues of paclitaxel (Taxol). (C) 2000 Elsevier Science Ltd. All rights reserved.
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页码：4485 / 4497
页数：13
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