Epstein-Barr virus-targeted immunotherapy for nasopharyngeal carcinoma

被引：35

作者：

Masmoudi, Amine ^{[1
]}

Toumi, Nabil

Khanfir, Afef

Kallel-Slimi, Lamia

Daoud, Jamel

Karray, Hela

Frikha, Mounir

机构：

[1] Habib Bourguiba Hosp, Dept Med Oncol, Sfax 3029, Tunisia

[2] Habib Bourguiba Hosp, Dept Radiotherapy, Sfax 3029, Tunisia

[3] Habib Bourguiba Hosp, Dept Microbiol, Sfax 3029, Tunisia

来源：

CANCER TREATMENT REVIEWS | 2007年 / 33卷 / 06期

关键词：

nasopharyngeal cancer; Epstein-Barr virus; adoptive immunotherapy; vaccination;

D O I：

10.1016/j.ctrv.2007.04.007

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Epstein-Barr virus (EBV) is constantly present in undifferentiated and poorly-differentiated nasopharyngeal cancer. Thus, tumour-associated viral antigens are potential targets for immunotherapy. Recently, both preclinical and early clinical studies have shown that various strategies can enhance EBV-specific immunity. Moreover, significant anti-tumour effect has been observed, and was generally correlated with biological response. The present review discusses the rational for EBV-targeted immunotherapy and summarises the latest developments in this area. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：499 / 505

页数：7

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