A phosphorescent rhenium(I) histone deacetylase inhibitor: mitochondrial targeting and paraptosis induction

被引：52

作者：

Ye, Rui-Rong ^{[1
]}

Tan, Cai-Ping ^{[1
]}

Lin, Yan-Nan ^{[1
]}

Ji, Liang-Nian ^{[1
]}

Mao, Zong-Wan ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Sch Chem & Chem Engn, MOE Key Lab Bioinorgan & Synthet Chem, Guangzhou 510275, Guangdong, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 39期

基金：

中国国家自然科学基金;

关键词：

BREAST-CANCER CELLS; ANTICANCER AGENTS; IN-VIVO; BIOLOGICAL EVALUATION; COMPLEXES; APOPTOSIS; MORPHOLOGY; PROBES; THERAPY; ACID;

D O I：

10.1039/c5cc02354h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this report, we designed a histone deacetylase-targeted phosphorescent Re(I) complex ReLMito. Colocalization studies suggested that ReLMito could specially localize to mitochondria. We also demonstrated that ReLMito could induce paraptosis in cancer cells. These features endowed the complex with potential to induce and monitor mitochondrial morphological changes during the paraptosis simultaneously.

引用

页码：8353 / 8356

页数：4

共 41 条

[1] Cytoplasmic sequestration of HDAC7 from mitochondrial and nuclear compartments upon initiation of apoptosis
Bakin, RE
Jung, MO
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (49) : 51218 - 51225
[2] Anticancer activities of histone deacetylase inhibitors
Bolden, Jessica E.
Peart, Melissa J.
Johnstone, Ricky W.
[J]. NATURE REVIEWS DRUG DISCOVERY, 2006, 5 (09) : 769 - 784
[3] The [(Cp)M(CO)3] (M=Re, 99mTc) Building Block for Imaging Agents and Bioinorganic Probes: Perspectives and Limitations
Can, Daniel
N'Dongo, Harmel W. Peindy
Spingler, Bernhard
Schmutz, Paul
Raposinho, Paula
Santos, Isabel
Alberto, Roger
[J]. CHEMISTRY & BIODIVERSITY, 2012, 9 (09) : 1849 - 1866
[4] [(Cp-R)M(CO)3] (M=Re or 99mTc) Arylsulfonamide, Arylsulfamide, and Arylsulfamate Conjugates for Selective Targeting of Human Carbonic Anhydrase IX
Can, Daniel
Spingler, Bernhard
Schmutz, Paul
Mendes, Filipa
Raposinho, Paula
Fernandes, Celia
Carta, Fabrizio
Innocenti, Alessio
Santos, Isabel
Supuran, Claudiu T.
Alberto, Roger
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2012, 51 (14) : 3354 - 3357
[5] Production of reactive oxygen species by mitochondria - Central role of complex III
Chen, Q
Vazquez, EJ
Moghaddas, S
Hoppel, CL
Lesnefsky, EJ
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (38) : 36027 - 36031
[6] Metal-Carbonyl Units for Vibrational and Luminescence Imaging: Towards Multimodality
Clede, Sylvain
Policar, Clotilde
[J]. CHEMISTRY-A EUROPEAN JOURNAL, 2015, 21 (03) : 942 - 958
[7] Collery P, 2014, ANTICANCER RES, V34, P1679
[8] Histone deacetylases (HDACs): characterization of the classical HDAC family
De Ruijter, AJM
Van Gennip, AH
Caron, HN
Kemp, S
Van Kuilenburg, ABP
[J]. BIOCHEMICAL JOURNAL, 2003, 370 : 737 - 749
[9] Targeting mitochondria for cancer therapy
Fulda, Simone
Galluzzi, Lorenzo
Kroemer, Guido
[J]. NATURE REVIEWS DRUG DISCOVERY, 2010, 9 (06) : 447 - 464
[10] Synthesis, characterisation and bioimaging of a fluorescent rhenium-containing PNA bioconjugate
Gasser, Gilles
Pinto, Antonio
Neumann, Sebastian
Sosniak, Anna M.
Seitz, Michael
Merz, Klaus
Heumann, Rolf
Metzler-Nolte, Nils
[J]. DALTON TRANSACTIONS, 2012, 41 (08) : 2304 - 2313

← 1 2 3 4 5 →