Biotransformation of 20(S)-protopanaxatriol by Aspergillus niger and the cytotoxicity of the resulting metabolites

被引：6
作者：
Chen, Guangtong [1 ]
Song, Yan [1 ]
Ge, Hongjuan [1 ]
Ren, Jie [2 ]
Yang, Xue [1 ]
Li, Jianlin [1 ]
机构：
[1] Nantong Univ, Sch Pharm, Nantong 226001, Peoples R China
[2] Changzhou Univ, Sch Pharmaceut Engn & Life Sci, Changzhou 213164, Peoples R China
来源：
PHYTOCHEMISTRY LETTERS | 2015年 / 11卷
基金：
中国国家自然科学基金;
关键词：
20(S)-Protopanaxatriol; Microbial transformation; Aspergillus niger AS 3.1858; Cytotoxicity; MICROBIAL TRANSFORMATION; DEOXYANDROGRAPHOLIDE; SAPONINS;
D O I：
10.1016/j.phytol.2014.11.006
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The microbial transformation of 20(S)-protopanaxatriol by cell suspension cultures of Aspergillus niger AS 3.1858 yielded metabolites 1-13. The chemical structures of these transformed products were elucidated based on various spectroscopic analyses, including 1D and 2D NMR and HRESIMS. Metabolites 3, 11, and 13 are new compounds. Furthermore, metabolite 3 exhibited relative better activity profile toward the tested seven cancer cell lines (Du-145, Hela, K562, K562/ADR, SH-SY5Y, HepG2, and MCF-7) than substrate and preliminary structure-activity relationships were concluded. (C) 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：111 / 115
页数：5
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