Is there an association between flow diverter fish mouthing and delayed-type hypersensitivity to metals?-a case-control study

被引:14
作者
Kocer, Naci [1 ]
Mondel, Prabath Kumar [1 ]
Yamac, Elif [1 ]
Kavak, Ayse [2 ]
Kizilkilic, Osman [1 ]
Islak, Civan [1 ]
机构
[1] Istanbul Univ, Cerrahpasa Med Fac, Div Neuroradiol, Dept Radiol, TR-34098 Istanbul, Turkey
[2] Bakirkoy Dr Sadi Konuk Training & Res Hosp, Dept Dermatol, Tevfik Saglam Cad 11,Zuhuratbaba Mah, TR-34147 Bakirkoy Istanbul, Turkey
关键词
Flow diverter; Fish mouthing; Delayed-type hypersensitivity; Contact allergy; In-stent stenosis; Patch test; EMBOLIZATION DEVICE; ANEURYSMS; COMPLICATIONS; PREVALENCE; EXPERIENCE; DIVERSION; COILING; ALLERGY;
D O I
10.1007/s00234-017-1910-3
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Flow diverters are increasingly used in the treatment of complex and giant intracranial aneurysms. However, they are associated with complications like late aneurysmal rupture. Additionally, flow diverters show focal structural decrease in luminal diameter without any intimal hyperplasia. This resembles a "fish mouth" when viewed en face. In this pilot study, we tested the hypothesis of a possible association between flow diverter fish-mouthing and delayed-type hypersensitivity to its metal constituents. We retrospectively reviewed patient records from our center between May 2010 and November 2015. A total of nine patients had flow diverter fish mouthing. A control group of 25 patients was selected. All study participants underwent prospective patch test to detect hypersensitivity to flow diverter metal constituents. Analysis was performed using logistic regression analysis and Wilcoxon sign rank sum test. Univariate and multivariate analyses were performed to test variables to predict flow diverter fish mouthing. The association between flow diverter fish mouthing and positive patch test was not statistically significant. In multivariate analysis, history of allergy and maximum aneurysm size category was associated with flow diverter fish mouthing. This was further confirmed on Wilcoxon sign rank sum test. The study showed statistically significant association between flow diverter fish mouthing and history of contact allergy and a small aneurysmal size. Further large-scale studies are needed to detect a statistically significant association between flow diverter fish mouthing and patch test. We recommend early and more frequent follow-up imaging in patients with contact allergy to detect flow diverter fish mouthing and its subsequent evolution.
引用
收藏
页码:1171 / 1178
页数:8
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