An Approach to 3-(Indo1-2-yl)succinimide Derivatives by Manganese Catalyzed C-H Activation

被引：109

作者：

Liu, Shuang-Liang ^{[1
]}

Li, Yang ^{[1
]}

Guo, Jun-Ru ^{[1
]}

Yang, Guang-Chao ^{[1
]}

Li, Xue-Hong ^{[1
]}

Gong, Jun-Fang ^{[1
]}

Song, Mao-Ping ^{[1
]}

机构：

[1] Zhengzhou Univ, Coll Chem & Mol Engn, Henan Key Lab Chem Biol & Organ Chem, Zhengzhou 450001, Henan, Peoples R China

来源：

ORGANIC LETTERS | 2017年 / 19卷 / 15期

基金：

中国国家自然科学基金;

关键词：

BOND ACTIVATION; ORGANIC-SYNTHESIS; C(SP(2))-H BONDS; MICHAEL ADDITION; DIRECTING GROUPS; FUNCTIONALIZATION; MALEIMIDES; INDOLES; ALKYNES; ACCESS;

D O I：

10.1021/acs.orglett.7b01795

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The manganese-catalyzed addition of C-2 position of indoles to maleimides has been achieved under additive-free conditions. The manganese catalyst exhibits excellent chemo- and regioselectivity, good functional group compatibility, and high catalytic efficiency. The substrate scope can also be extended to maleates, ethyl acrylate, 1,4-dihydro-1,4-epoxynaphthalene, pyrroles, and 2-phenylpyridine, which further demonstrates the universality of this straightforward approach.

引用

页码：4042 / 4045

页数：4

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