An Approach to 3-(Indo1-2-yl)succinimide Derivatives by Manganese Catalyzed C-H Activation

被引：108
作者：
Liu, Shuang-Liang [1 ]
Li, Yang [1 ]
Guo, Jun-Ru [1 ]
Yang, Guang-Chao [1 ]
Li, Xue-Hong [1 ]
Gong, Jun-Fang [1 ]
Song, Mao-Ping [1 ]
机构：
[1] Zhengzhou Univ, Coll Chem & Mol Engn, Henan Key Lab Chem Biol & Organ Chem, Zhengzhou 450001, Henan, Peoples R China
来源：
ORGANIC LETTERS | 2017年 / 19卷 / 15期
基金：
中国国家自然科学基金;
关键词：
BOND ACTIVATION; ORGANIC-SYNTHESIS; C(SP(2))-H BONDS; MICHAEL ADDITION; DIRECTING GROUPS; FUNCTIONALIZATION; MALEIMIDES; INDOLES; ALKYNES; ACCESS;
D O I：
10.1021/acs.orglett.7b01795
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The manganese-catalyzed addition of C-2 position of indoles to maleimides has been achieved under additive-free conditions. The manganese catalyst exhibits excellent chemo- and regioselectivity, good functional group compatibility, and high catalytic efficiency. The substrate scope can also be extended to maleates, ethyl acrylate, 1,4-dihydro-1,4-epoxynaphthalene, pyrroles, and 2-phenylpyridine, which further demonstrates the universality of this straightforward approach.
引用
收藏
页码：4042 / 4045
页数：4
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