A hypothesis on the identification of the editing enzyme in plant organelles

被引：200

作者：

Salone, Veronique

Ruedinger, Mareike

Polsakiewicz, Monika

Hoffmann, Beate

Groth-Malonek, Milena

Szurek, Boris

Small, Ian

Knoop, Volker

Lurin, Claire

机构：

[1] URGV, F-91057 Evry, France

[2] Univ Western Australia, ARC Ctr Excellence Plant Energy Biol, Nedlands, WA 6009, Australia

[3] IZMB, Abt Mol Evolut, D-53115 Bonn, Germany

来源：

FEBS LETTERS | 2007年 / 581卷 / 22期

基金：

澳大利亚研究理事会;

关键词：

RNA editing; PPR protein; DYW domain; plant evolution;

D O I：

10.1016/j.febslet.2007.07.075

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

RNA editing in plant organelles is an enigmatic process leading to conversion of cytidines into uridines. Editing specificity is determined by proteins; both those known so far are pentatricopeptide repeat (PPR) proteins. The enzyme catalysing RNA editing in plants is still totally unknown. We propose that the DYW domain found in many higher plant PPR proteins is the missing catalytic domain. This hypothesis is based on two compelling observations: (i) the DYW domain contains invariant residues that match the active site of cytidine deaminases; (ii) the phylogenetic distribution of the DYW domain is strictly correlated with RNA editing. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：4132 / 4138

页数：7

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