Utilizing magnetic resonance techniques to study membrane interactions of amyloid peptides

被引：5
|
作者：
Rajput, Sunnia [1 ]
Sani, Marc-Antoine [1 ,2 ]
Keizer, David W. [1 ]
Separovic, Frances [1 ,2 ]
机构：
[1] Univ Melbourne, Bio21 Mol Sci & Biotechnol Inst, Melbourne, Vic 3010, Australia
[2] Univ Melbourne, Sch Chem, Melbourne, Vic 3010, Australia
来源：
BIOCHEMICAL SOCIETY TRANSACTIONS | 2021年 / 49卷 / 03期
基金：
澳大利亚研究理事会;
关键词：
IN-CELL NMR; BETA-PEPTIDE; ALZHEIMERS-DISEASE; PRECURSOR PROTEIN; ENDOGENOUS SEED; CHEMICAL-SHIFTS; AGGREGATION; MODEL; GM1; CHOLESTEROL;
D O I：
10.1042/BST20201244
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Alzheimer's disease (AD) is a common neurodegenerative condition that involves the extracellular accumulation of amyloid plaques predominantly consisting of A beta peptide aggregates. The amyloid plaques and soluble oligomeric species of A beta are believed to be the major cause of synaptic dysfunction in AD brain and their cytotoxic mechanisms have been proposed to involve interactions with cell membranes. In this review, we discuss our solid-state nuclear magnetic resonance (ssNMR) studies of A beta interactions with model membranes.
引用
收藏
页码：1457 / 1465
页数：9
相关论文
共 50 条
  • [1] Magnetic resonance studies of β-amyloid peptides
    Lau, TL
    Barnham, KJ
    Curtain, CC
    Masters, CL
    Separovic, F
    AUSTRALIAN JOURNAL OF CHEMISTRY, 2003, 56 (05) : 349 - 356
  • [2] Metal effects on the membrane interactions of amyloid-β peptides
    John D. Gehman
    Caitlin C. O’Brien
    Fazel Shabanpoor
    John D. Wade
    Frances Separovic
    European Biophysics Journal, 2008, 37 : 333 - 344
  • [3] Metal effects on the membrane interactions of amyloid-β peptides
    Gehman, John D.
    O'Brien, Caitlin C.
    Shabanpoor, Fazel
    Wade, John D.
    Separovic, Frances
    EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 2008, 37 (03): : 333 - 344
  • [4] Probing into the interaction of β-amyloid peptides with bilayer lipid membrane by electrochemical techniques
    Zhao, Jing
    Gao, Tao
    Yan, Yalin
    Chen, Guifang
    Li, Genxi
    ELECTROCHEMISTRY COMMUNICATIONS, 2013, 30 : 26 - 28
  • [5] Interactions of Metal Ions with α Synuclein and Amyloid β Peptides
    Valensin, Daniela
    Kozlowski, Henryk
    Tessari, Isabella
    Acqua, Simone Dell'
    Bubacco, Luigi
    Casella, Luigi
    Gaggelli, Elena
    Valensin, Gianni
    INTERNATIONAL CONFERENCE OF COMPUTATIONAL METHODS IN SCIENCES AND ENGINEERING 2014 (ICCMSE 2014), 2014, 1618 : 115 - 118
  • [6] Interactions of Amyloid-β with Membrane Proteins
    Wiatrak, Benita
    Piasny, Janusz
    Kuzniarski, Amadeusz
    Gasiorowski, Kazimierz
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (11)
  • [7] Membrane-Protein Interactions Are Key to Understanding Amyloid Formation
    Straub, John E.
    Thirumalai, D.
    JOURNAL OF PHYSICAL CHEMISTRY LETTERS, 2014, 5 (03): : 633 - 635
  • [8] Studies on the Interactions of Copper and Zinc Ions with β-Amyloid Peptides by a Surface Plasmon Resonance Biosensor
    Yao, Fujun
    Zhang, Ruiping
    Tian, He
    Li, Xiangjun
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2012, 13 (09) : 11832 - 11843
  • [9] Amyloid β Peptides Aggregation in a Mixed Membrane Bilayer: A Molecular Dynamics Study
    Zhao, Li Na
    Chiu, See-Wing
    Benoit, Jerome
    Chew, Lock Yue
    Mu, Yuguang
    JOURNAL OF PHYSICAL CHEMISTRY B, 2011, 115 (42) : 12247 - 12256
  • [10] Not Oligomers but Amyloids are Cytotoxic in the Membrane-Mediated Amyloidogenesis of Amyloid- Peptides
    Itoh, Naoya
    Takada, Eri
    Okubo, Kaori
    Yano, Yoshiaki
    Hoshino, Masaru
    Sasaki, Akira
    Kinjo, Masataka
    Matsuzaki, Katsumi
    CHEMBIOCHEM, 2018, 19 (05) : 430 - 433
12345