Aptamers as the 'capturing' agents in aptamer-based capture assays

被引：32

作者：

Citartan, Marimuthu ^{[1
]}

Ch'ng, Ewe-Seng ^{[1
]}

Rozhdestvensky, Timofey S. ^{[2
]}

Tang, Thean-Hock ^{[1
]}

机构：

[1] Univ Sains Malaysia, AMDI, Kepala Batas 13200, Penang, Malaysia

[2] Univ Hosp Muenster, Dept Med TRAM, Von Esmarch Str 56, D-48149 Munster, Germany

来源：

MICROCHEMICAL JOURNAL | 2016年 / 128卷

关键词：

Aptamer; Target recognition; AptaCapture assay; NUCLEIC-ACID APTAMERS; LABEL-FREE; HIGH-AFFINITY; CANCER-CELLS; RNA APTAMER; ELECTROCHEMICAL DETECTION; STAPHYLOCOCCUS-AUREUS; BIOMARKER DISCOVERY; ENDOTHELIAL-CELLS; BINDING PROTEINS;

D O I：

10.1016/j.microc.2016.04.019

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Aptamers are widely used as diagnostic agents due to their specificity and high binding affinity to their cognate target. Apart from diagnostic applications, aptamers can also be employed to capture their cognate target. Aptamer-based capture (AptaCapture) assays enable capture of the target by the aptamers followed by target purification. This review focuses on the immobilization strategies of aptamers, different target purification techniques, and applications of AptaCapture assays. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：187 / 197

页数：11

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