PET-CT for radiotherapy treatment planning and response monitoring in solid tumors

被引：67

作者：

Bussink, Johan ^{[1
]}

Kaanders, Johannes H. A. M. ^{[1
]}

van der Graaf, Winette T. A. ^{[2
]}

Oyen, Wim J. G. ^{[3
]}

机构：

[1] Radboud Univ Nijmegen, Med Ctr, Dept Radiat Oncol, NL-6500 HB Nijmegen, Netherlands

[2] Radboud Univ Nijmegen, Med Ctr, Dept Med Oncol, NL-6500 HB Nijmegen, Netherlands

[3] Radboud Univ Nijmegen, Med Ctr, Dept Nucl Med, NL-6500 HB Nijmegen, Netherlands

来源：

NATURE REVIEWS CLINICAL ONCOLOGY | 2011年 / 8卷 / 04期

关键词：

POSITRON-EMISSION-TOMOGRAPHY; CELL LUNG-CANCER; F-18 FLUORODEOXYGLUCOSE UPTAKE; NECK-CANCER; RADIATION ONCOLOGY; CONVENTIONAL RADIOTHERAPY; ACCELERATED RADIOTHERAPY; BREAST-CANCER; ESOPHAGOGASTRIC JUNCTION; IMAGING PROLIFERATION;

D O I：

10.1038/nrclinonc.2010.218

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

PET imaging has evolved as an indispensible tool for staging in oncology. Multiple quantitative measurements can be performed, enabling the effects of treatment to be monitored before changes are detectable with the use of conventional imaging modalities. PET tracers are available to visualize and quantify the most important mechanisms of resistance to radiotherapy and chemoradiotherapy. Reproducibility of these tracers depends on the particular tracer and the underlying biology of the process that is being investigated. PET enables clinicians to select patients for intensified treatment on the basis of resistance mechanisms taking place at the molecular level. From translational studies and randomized trials, it has become clear that appropriate patient selection can prevent unnecessary rejection of various treatment options through the observation of individual patients rather than only looking at the results of a large study population.

引用

页码：233 / 242

页数：10

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