Elevated expression of urotensin II and its receptor in diabetic cardiomyopathy

被引：25
作者：
Dai, Hong-Yan [1 ,2 ,3 ]
Guo, Xin-Gui [3 ]
Ge, Zhi-Ming [1 ,2 ]
Li, Zhen-Hua [1 ,2 ]
Yu, Xiao-Jing [4 ]
Tang, Meng-Xiong [1 ,2 ]
Zhang, Yun [1 ,2 ]
机构：
[1] Shandong Univ, Qilu Hosp, Chinese Minist Educ, Key Lab Cardiovasc Remodling & Funct Res, Jinan 250100, Shandong, Peoples R China
[2] Shandong Univ, Qilu Hosp, Chinese Minist Publ Hlth, Jinan 250100, Shandong, Peoples R China
[3] Qingdaos Municipal Hosp, Dept Cardiol, Qingdao, Shandong, Peoples R China
[4] Shandong Univ, Qilu Hosp, Dept Dermatol, Jinan 250100, Shandong, Peoples R China
来源：
JOURNAL OF DIABETES AND ITS COMPLICATIONS | 2008年 / 22卷 / 02期
关键词：
urotensin II; diabetic cardiomyopathy; cardiac remodeling;
D O I：
10.1016/j.jdiacomp.2006.10.008
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Objective: Urotensin II (UII) is a somatostatin-like peptide recently identified to have several cardiovascular effects, including potent vasoactive, cardiac inotropic and chronotropic properties. Our aim was to determine the degree of expression of UII and UII receptor (UT) in the myocardium of rats with streptozotocin (STZ)-induced diabetes. Methods: Real-time polymerase chain reaction, Western blot, and immunohistochemistry were used to determine the degree of expression and location of UII and UT in the myocardium of STZ-induced diabetic rats. Results: UII and UT expression were significantly enhanced in the myocardium of rats with diabetes compared with healthy controls on both messenger RNA and protein levels. Both UII and UT protein expression were mainly concentrated in the cardiomyocytes, endothelial cells, cardiac fibroblasts, and smooth muscle cells of diabetic cardiomyopathy (DCM). Conclusions: Our results suggest a possible role for the UII/UT system in the pathophysiology of DCM. (C) 2008 Elsevier Inc. All rights reserved.
引用
收藏
页码：137 / 143
页数：7
相关论文
共 38 条
[11]   PATHOMORPHOLOGIC ASPECTS OF MUSCULAR TISSUE IN DIABETES-MELLITUS [J].
FISCHER, VW ;
BARNER, HB ;
LAROSE, LS .
HUMAN PATHOLOGY, 1984, 15 (12) :1127-1136
[12]   Diabetic cardiomyopathy: mechanisms, diagnosis and treatment [J].
Hayat, SA ;
Patel, B ;
Khattar, RS ;
Malik, RA .
CLINICAL SCIENCE, 2004, 107 (06) :539-557
[13]   Contributions of endothelin-1 and sodium hydrogen exchanger-1 in the diabetic myocardium [J].
Hileeto, D ;
Cukiernik, M ;
Mukherjee, S ;
Evans, T ;
Barbin, Y ;
Downey, D ;
Karmazyn, M ;
Chakrabarti, S .
DIABETES-METABOLISM RESEARCH AND REVIEWS, 2002, 18 (05) :386-394
[14]   Inhibition of angiotensin type 1 receptor prevents decline of glucose transporter (GLUT4) in diabetic rat heart [J].
Hoenack, C ;
Roesen, P .
DIABETES, 1996, 45 :S82-S87
[15]   Urotensin-II-mediated cardiomyocyte hypertrophy: effect of receptor antagonism and role of inflammatory mediators [J].
Johns, DG ;
Ao, ZH ;
Naselsky, D ;
Herold, CL ;
Maniscalco, K ;
Sarov-Blat, L ;
Steplewski, K ;
Aiyar, N ;
Douglas, SA .
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2004, 370 (04) :238-250
[16]   Myocardial angiotensin II (Ang II) receptors in diabetic rats [J].
Khatter, JC ;
Sadri, P ;
Zhang, M ;
Hoeschen, RJ .
MYOCARDIAL PRESERVATION, PRECONDITIONING, AND ADAPTATION, 1996, 793 :466-472
[17]   Angiotensin blockade improves cardiac and renal complications of type II diabetic rats [J].
Kim, S ;
Wanibuchi, H ;
Hamaguchi, A ;
Miura, K ;
Yamanaka, S ;
Iwao, H .
HYPERTENSION, 1997, 30 (05) :1054-1061
[18]   Increased expression of urotensin II and urotensin II receptor in human diabetic nephropathy [J].
Langham, RG ;
Kelly, DJ ;
Gow, RM ;
Zhang, Y ;
Dowling, JK ;
Thomson, NM ;
Gilbert, RE .
AMERICAN JOURNAL OF KIDNEY DISEASES, 2004, 44 (05) :826-831
[19]   Elevated plasma human urotensin-II-like immunoreactivity in ischemic cardiomyopathy [J].
Lapp, H ;
Boerrigter, G ;
Costello-Boerrigter, LC ;
Jaekel, K ;
Scheffold, T ;
Krakau, I ;
Schramm, M ;
Guelker, H ;
Stasch, JP .
INTERNATIONAL JOURNAL OF CARDIOLOGY, 2004, 94 (01) :93-97
[20]   Diabetic cardiomyopathy: An overview [J].
LeWinter, MM .
CORONARY ARTERY DISEASE, 1996, 7 (02) :95-98
1234