Discovery of cytochrome p450 1B1 inhibitors as new promising anti-cancer agents

被引：69
作者：
Chun, YJ
Kim, SH
机构：
[1] Seoul Natl Univ, Coll Pharm, Inst Nat Prod Res, Seoul 110460, South Korea
[2] Chung Ang Univ, Coll Pharm, Seoul 156756, South Korea
来源：
MEDICINAL RESEARCH REVIEWS | 2003年 / 23卷 / 06期
关键词：
cytochrome P4501B1; CYPI inhibitors; stilbene; anti-cancer; natural products;
D O I：
10.1002/med.10050
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Human cytochrome P450 (CYP)1B1 is a major enzyme for carcinogenic estrogen metabolism and involved in the metabolic activation of procarcinogens of the polycyclic aromatic hydrocarbons (PAHs). CYP1B1 is known to be expressed at a high frequency in various human cancers, but not in normal tissues. It also plays an important role in the metabolism of various anticancer drugs. These findings suggest inhibition of CYP1B1 as a new oncological therapeutic strategy. Several natural and synthetic compounds have been studied in an effort to find the isoform-specific inhibitors of the CYP1 subfamily. A survey of the inhibitors of CYP1B1 and other related inhibitors of the CYP1 subfamily is provided in this review. (C) 2003 Wiley Periodicals, Inc.
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收藏
页码：657 / 668
页数：12
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