EXERCISE PRECONDITIONING AND BRAIN ISCHEMIC TOLERANCE

被引：99
作者：
Zhang, F. [1 ,2 ]
Wu, Y. [1 ,2 ]
Jia, J. [1 ,2 ]
机构：
[1] Fudan Univ, Huashan Hosp, Dept Rehabil, Shanghai 200040, Peoples R China
[2] Fudan Univ, Coll Med, Dept Sports Med & Rehabil, Shanghai 200032, Peoples R China
来源：
NEUROSCIENCE | 2011年 / 177卷
关键词：
exercise preconditioning; brain ischemic tolerance; inflammatory response; neuron apoptosis; blood-brain barrier; cerebral vasculature; FOCAL CEREBRAL-ISCHEMIA; PHYSICAL-ACTIVITY; HIPPOCAMPAL CA1; BARRIER DYSFUNCTION; NEURONAL APOPTOSIS; ARTERY OCCLUSION; PROGENITOR CELLS; STROKE RISK; TNF-ALPHA; IN-VIVO;
D O I：
10.1016/j.neuroscience.2011.01.018
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
It is well established that physical exercise can exert neuroprotection both in clinical settings and animal experiments. A series of studies have demonstrated that physical exercise may be a promising preconditioning method to induce brain ischemic tolerance through the promotion of angiogenesis, mediation of the inflammatory response, inhibition of glutamate over-activation, protection of the blood brain barrier (BBB) and inhibition of apoptosis. Through these mechanisms, exercise preconditioning may reduce the neural deficits associated with ischemia and the development of brain infarction and thus provide brain ischemic tolerance. An awareness of the benefits of exercise preconditioning may lead more patients to accept exercise therapy in cases of ischemic stroke. (C) 2011 IBRO. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：170 / 176
页数：7
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