4,5-Dihydroxyimidazolidin-2-ones in α-ureidoalkylation of N-carboxyalkyl-, N-hydroxyalkyl-, and N-(aminoalkyl)ureas 4. α-Ureidoalkylation of N-(2-acetylaminoethyl)ureas

被引：12

作者：

Gazieva, G. A. ^{[1
]}

Lozhkin, P. V. ^{[1
]}

Baranov, V. V. ^{[1
]}

Kravchenko, A. N. ^{[1
]}

Makhova, N. N. ^{[1
]}

机构：

[1] Russian Acad Sci, ND Zelinskii Organ Chem Inst, Moscow 119991, Russia

来源：

RUSSIAN CHEMICAL BULLETIN | 2010年 / 59卷 / 03期

基金：

俄罗斯基础研究基金会;

关键词：

alpha-ureidoalkylation; N-carbamoylation; N-(2-acetylaminoethyl)glycolurils; 4,5-dihydroxyimidazolidin-2-ones; N-(2-acetylaminoethyl)ureas; GLYCOLURIL;

D O I：

10.1007/s11172-010-0117-0

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

alpha-Ureidoalkylation of N-(2-acetylaminoethyl) ureas with various 4,5-dihydroxyimidazoli-din-2-ones was systematically studied. Novel N-(2-acetylaminoethyl)glycolurils were obtained. Their yields were found to decrease both when moving from 1,3-H-2- to 1,3-Alk(2)-4,5-dihydroxyimidazolidin-2-ones and when increasing the size of the substituent at the second N atom in the starting acetylaminoethylurea. The higher yields were achieved with 4,5-diphenyl-4,5-dihydroxyimidazolidin-2-one as the starting compound. 2-(2-Acetylaminoethyl)-4-methylglycoluril exhibits nootropic activity.

引用

页码：642 / 646

页数：5

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