Characterization of CdHgTe/CdS QDs for Near Infrared Fluorescence Imaging of Spinal Column in a Mouse Model

被引：27

作者：

Chen, Haiyan ^{[1
]}

Cui, Sisi ^{[1
]}

Tu, Zhenzhen ^{[1
]}

Ji, Jinzi ^{[1
]}

Zhang, Jun ^{[1
]}

Gu, Yueqing ^{[1
]}

机构：

[1] China Pharmaceut Univ, Sch Life Sci & Technol, Dept Biomed Engn, Nanjing 210009, Peoples R China

来源：

PHOTOCHEMISTRY AND PHOTOBIOLOGY | 2011年 / 87卷 / 01期

关键词：

CORE-SHELL NANOCRYSTALS; QUANTUM DOTS; IN-VIVO; LIVE CELLS; EXPOSURE; PROBES; LUMINESCENCE; EXPRESSION; TOXICITY; TARGET;

D O I：

10.1111/j.1751-1097.2010.00828.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Near infrared (NIR) CdHgTe/CdS quantum dots (QDs) were successfully prepared by a green synthetic route. The characteristics such as morphology, size, spectra, stability and toxicity were investigated in detail. The fluorescence wavelength of CdHgTe/CdS QDs could be adjusted to the NIR range (812 nm), which made the in vivo NIR imaging possible. The in vivo dynamic biodistribution of CdHgTe/CdS QDs in a mouse model was monitored by an NIR imaging system. Results indicated that CdHgTe/CdS QDs with a diameter of about 5.8 nm targeted to spinal column effectively. Further imaging of the dissected spine disclosed that QDs targeted to vertebra rather than spinal cord. The high fluorescence intensity together with targeting effect makes CdHgTe/CdS QDs particular candidates for imaging purposes in experimental animal models of vertebral injury.

引用

页码：72 / 81

页数：10

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