Association of necrotizing enterocolitis with anemia and packed red blood cell transfusions in preterm infants

被引：141

作者：

Singh, R. ^{[1
,2
]}

Visintainer, P. F.

Frantz, I. D., III ^{[3
]}

Shah, B. L.

Meyer, K. M.

Favila, S. A. ^{[4
]}

Thomas, M. S. ^{[4
]}

Kent, D. M. ^{[2
,3
]}

机构：

[1] Baystate Childrens Hosp, Div Newborn Med, Springfield, MA 01199 USA

[2] Tufts CTSI, Boston, MA USA

[3] Tufts Med Ctr, Boston, MA USA

[4] Tufts Univ, Sch Med, Boston, MA 02111 USA

来源：

JOURNAL OF PERINATOLOGY | 2011年 / 31卷 / 03期

基金：

美国国家卫生研究院;

关键词：

transfusion-related gut injury; hematocrit; temporal association; early NEC; late NEC; PREMATURE-INFANTS; RANDOMIZED-TRIAL; EPIDEMIOLOGY; MORBIDITY; MORTALITY; RISK;

D O I：

10.1038/jp.2010.145

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: To determine association of anemia and red blood cell (RBC) transfusions with necrotizing enterocolitis (NEC) in preterm infants. Study Design: A total of 111 preterm infants with NEC >= stage 2a were compared with 222 matched controls. In all, 28 clinical variables, including hematocrit (Hct) and RBC transfusions were recorded. Propensity scores and multivariate logistic regression models were created to examine effects on the risk of NEC. Result: Controlling for other factors, lower Hct was associated with increased odds of NEC (odds ratio (OR) = 1.10, P = 0.01). RBC transfusion has a temporal relationship with NEC onset. Transfusion within 24 h (OR = 7.60, P = 0.001) and 48 h (OR = 5.55, P = 0.001) has a higher odds of developing NEC but this association is not significant by 96 h (OR = 2.13, P = 0.07), post-transfusion. Conclusion: Anemia may increase the risk of developing NEC in preterm infants. RBC transfusions are temporally related to NEC. Prospective studies are needed to better evaluate the potential influence of transfusions on the development of NEC. Journal of Perinatology (2011) 31, 176-182; doi:10.1038/jp.2010.145; published online 27 January 2011

引用

页码：176 / 182

页数：7

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