Human placental biology at single-cell resolution: a contemporaneous review

被引：15

作者：

Barrozo, E. R. ^{[1
]}

Aagaard, K. M. ^{[1
]}

机构：

[1] Baylor Coll Med, Dept Obstet & Gynecol, Div Maternal Fetal Med, 1 Baylor Plaza, Houston, TX 77030 USA

来源：

BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY | 2022年 / 129卷 / 02期

关键词：

Decidua; multi-omics; pregnancy; scRNA-seq; trophoblast; RNA-SEQ REVEALS; TROPHOBLAST; TRANSCRIPTOMICS; DIFFERENTIATION; RECONSTRUCTION; ACTIVATION; SARS-COV-2;

D O I：

10.1111/1471-0528.16970

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Single-cell technologies capture cellular heterogeneity to focus on previously poorly described subpopulations of cells. Work by our laboratory and many others has metagenomically characterised a low biomass intrauterine microbial community, alongside microbial transcripts, antigens and metabolites, but the functional importance of low biomass microbial communities in placental immuno-microenvironments is still being elucidated. Given their hypothesised role in modulating inflammation and immune ontogeny to enable tolerance of beneficial microbes while warding off pathogens, there is a need for single-cell resolution. Herein, we summarise the potential for mechanistic understanding of these and other key fundamental early developmental processes by applying single-cell approaches.

引用

页码：208 / 220

页数：13

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