Post-vaccination infection rates and modification of COVID-19 symptoms in vaccinated UK school-aged children and adolescents: A prospective longitudinal cohort study

被引：14

作者：

Molteni, Erika ^{[1
]}

Canas, Liane S. ^{[1
]}

Kla, Kerstin ^{[1
]}

Deng, Jie ^{[1
]}

Bhopal, Sunil S. ^{[2
]}

Hughes, Robert C. ^{[3
]}

Chen, Liyuan ^{[1
]}

Murray, Benjamin ^{[1
]}

Kerfoot, Eric ^{[1
]}

Antonelli, Michela ^{[1
]}

Sudre, Carole H. ^{[1
,10
]}

Pujol, Joan Capdevila ^{[4
]}

Polidori, Lorenzo ^{[4
]}

May, Anna ^{[4
]}

Hammers, Prof Alexander ^{[1
]}

Wolf, Jonathan ^{[4
]}

Spector, Prof Tim D. ^{[5
]}

Steves, Claire J. ^{[5
,6
]}

Ourselin, Prof Sebastien ^{[1
]}

Absoud, Michael ^{[7
,8
]}

Modat, Marc ^{[1
]}

Duncan, Prof Emma L. ^{[5
,9
,11
]}

机构：

[1] Kings Coll London, Sch Biomed Engn & Imaging Sci, London, England

[2] Newcastle Univ, Populat Hlth Sci Inst, Fac Med Sci, Newcastle Upon Tyne, England

[3] Fac Epidemiol & Populat Hlth, London Sch Hyg & Trop Med, Dept Populat Hlth, Keppel St, London, England

[4] Zoe Ltd, London, England

[5] Kings Coll London, Dept Twin Res & Genet Epidemiol, London, England

[6] Guys & St ThomasNHS Fdn Trust, Dept Aging & Hlth, London, England

[7] Evelina London Childrens Hosp, St Thomas Hosp, Acad Hlth Sci Ctr, Childrens Neurosci, London, England

[8] Kings Coll London, Fac Life Sci & Med, Sch Life Course Sci, Dept Women & Childrens Hlth, London, England

[9] Guys & St ThomasNHS Fdn trust, Dept Endocrinol, London, England

[10] UCL, Dept Populat Hlth Sci, MRC Unit Lifelong Hlth & Ageing, London, England

[11] Kings Coll London, Sch Life Course Sci, Dept Twin Res & Genet Epidemiol, London WC2R 2LS, England

来源：

LANCET REGIONAL HEALTH-EUROPE | 2022年 / 19卷

基金：

英国科研创新办公室; 英国工程与自然科学研究理事会; 英国惠康基金; 英国医学研究理事会;

关键词：

SARS-CoV-2; vaccination; COVID-19; BNT162b2 vaccine effectiveness; SARS-CoV-2 vaccination in children; Paediatrics;

D O I：

10.1016/j.lanepe.2022.100429

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Background We aimed to explore the effectiveness of one-dose BNT162b2 vaccination upon SARS-CoV-2 infection, its effect on COVID-19 presentation, and post-vaccination symptoms in children and adolescents (CA) in the UK during periods of Delta and Omicron variant predominance. Methods In this prospective longitudinal cohort study, we analysed data from 115,775 CA aged 12-17 years, proxy -reported through the Covid Symptom Study (CSS) smartphone application. We calculated post-vaccination infection risk after one dose of BNT162b2, and described the illness profile of CA with post-vaccination SARS-CoV-2 infection, compared to unvaccinated CA, and post-vaccination side-effects. Findings Between August 5, 2021 and February 14, 2022, 25,971 UK CA aged 12-17 years received one dose of BNT162b2 vaccine. The probability of testing positive for infection diverged soon after vaccination, and was lower in CA with prior SARS-CoV-2 infection. Vaccination reduced proxy-reported infection risk (-80.4% (95% CI-0.82-0.78) and-53.7% (95% CI-0.62-0.43) at 14-30 days with Delta and Omicron variants respectively, and-61.5% (95% CI-0.74-0.44) and-63.7% (95% CI-0.68-0.59) after 61-90 days). Vaccinated CA who contracted SARS-CoV-2 during the Delta period had milder disease than unvaccinated CA; during the Omicron period this was only evident in children aged 12-15 years. Overall disease profile was similar in both vaccinated and unvaccinated CA. Post-vaccination local side-effects were common, systemic side-effects were uncommon, and both resolved within few days (3 days in most cases). Interpretation One dose of BNT162b2 vaccine reduced risk of SARS-CoV-2 infection for at least 90 days in CA aged 12-17 years. Vaccine protection varied for SARS-CoV-2 variant type (lower for Omicron than Delta variant), and was enhanced by pre-vaccination SARS-CoV-2 infection. Severity of COVID-19 presentation after vaccination was generally milder, although unvaccinated CA also had generally mild disease. Overall, vaccination was well-tolerated. Copyright (C) 2022 The Author(s). Published by Elsevier Ltd.

引用

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