Recent advances in cytokines: Therapeutic implications for inflammatory bowel diseases

被引：56

作者：

Bouguen, Guillaume ^{[2
]}

Chevaux, Jean-Baptiste ^{[1
]}

Peyrin-Biroulet, Laurent ^{[1
]}

机构：

[1] Univ Hosp Nancy, INSERM, Dept Hepatogastroenterol, U954, F-54511 Vandoeuvre Les Nancy, France

[2] Univ Hosp Rennes, INSERM, Dept Hepatogastroenterol, UMR991, F-35000 Rennes, France

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2011年 / 17卷 / 05期

关键词：

Inflammatory bowel disease; Ulcerative colitis; Crohn's disease; Cytokine; Pathophysiology; Biological therapy; TUMOR-NECROSIS-FACTOR; ACTIVE CROHNS-DISEASE; RECOMBINANT HUMAN INTERLEUKIN-10; ANTIINTERFERON-GAMMA ANTIBODY; RESISTANT ULCERATIVE-COLITIS; PLACEBO-CONTROLLED TRIAL; GENOME-WIDE ASSOCIATION; HUMAN-ENDOTHELIAL-CELLS; MONOCLONAL-ANTIBODY; DOUBLE-BLIND;

D O I：

10.3748/wjg.v17.i5.547

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Inflammatory bowel diseases (IBDs) are complex and chronic disabling conditions resulting from a dysregulated dialogue between intestinal microbiota and components of both the innate and adaptive immune systems. Cytokines are essential mediators between activated immune and non-immune cells, including epithelial and mesenchymal cells. They are immunomodulatory peptides released by numerous cells and these have significant effects on immune function leading to the differentiation and survival of T cells. The physiology of IBD is becoming a very attractive field of research for development of new therapeutic agents. These include cytokines involved in intestinal immune inflammation. This review will focus on mechanisms of action of cytokines involved in IBD and new therapeutic opportunities for these diseases. (C) 2011 Baishideng. All rights reserved.

引用

页码：547 / 556

页数：10

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