Multicomponent membranes on solid substrates Interfaces for protein binding

被引:13
作者
Steinem, Claudia [1 ]
Janshoff, Andreas [2 ]
机构
[1] Univ Gottingen, Inst Organ & Biomol Chem, D-37077 Gottingen, Germany
[2] Univ Gottingen, Inst Phys Chem, D-37077 Gottingen, Germany
关键词
Adsorption; Atomic force microscopy; Cooperativity; Lipid anchor; Rafts; Phase separation; SUPPORTED LIPID-BILAYERS; EXCLUDED SURFACE-AREA; ANNEXIN A1; COOPERATIVE ADSORPTION; BIOLOGICAL-MEMBRANES; PHYSICAL-PROPERTIES; VESICLE ADSORPTION; ORDERED DOMAINS; PLANAR; MODEL;
D O I
10.1016/j.cocis.2010.06.004
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Even though lipid membranes deposited on a solid support are now used for more than 20 years as a model system for cellular membranes their potential has as yet not been fully exploited Only in recent years the composition of solid supported membranes became more and more complex which is a prerequisite for the elucidation of biologically relevant protein adsorption processes Multicomponent bilayers resemble the heterogeneity of the biological membrane which is composed of hundreds of different lipids varying in their headgroup and acyl chain composition The development of a multitude of elaborated surface sensitive techniques allows to study the phase behavior of these membranes and their interaction with proteins some of which will be highlighted in this review (C) 2010 Elsevier Ltd All rights reserved
引用
收藏
页码:479 / 488
页数:10
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